## DCAF11
- **UniProt:** Q8TEB1 (WDR23) · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other` ; **PN-node mapping:** group node `Cul4A/Cul4B substrate receptor` mapped → GO:1990756 (ok_for_propagation, new_to_goa); class context_only (GO:0061630, too_broad).
- **Consistency:** Fully consistent. Deep-research notes, review, and PN all describe DCAF11 as a CRL4 substrate receptor (WD40 + WDxR docking on DDB1) with two validated substrates: NRF2/NFE2L2 (PMID:31586112) and CENP-A (PMID:34758320). Better characterized than DCAF10. No contradictions.
- **PN story / NEW pressure:** Already captured. Unlike DCAF10, the DCAF11 review already MODIFIES a bare protein-binding annotation to GO:1990756 (proposed_replacement_terms on the PMID:16949367 DDB1/CUL4 IPI) AND uses GO:1990756 as the molecular_function of its first core_function. PN's projected GO:1990756 thus duplicates an MF the review already asserts. No additional ADD needed. (PN flags it new_to_goa because GOA proper still only has bare protein binding — the review's MODIFY is the mechanism to introduce it.) Substrate-adaptor MF only; no catalytic RING (distinct from COP1).
- **Mapping strategy:** Correct. Group → GO:1990756 substrate-adaptor MF is right; class GO:0061630 correctly too_broad. Projection is precisely scoped, not over-reaching (contrast the rejected TOMM20/HSPA8/RAB7A broader-term cases). No mapping change.
- **Evidence alignment:** PN cites 17588513 (DCAF review). Review's gene-specific evidence (PMID:16949367 founding DCAF, 16964240 DDB1-CUL4A architecture, 31586112 NRF2, 34758320 CENP-A) does not directly overlap the single PN citation but is concordant at the family/mechanism level.
- **Verdict:** Consistent; mapping sound; no edits. GO:1990756 already in review (core_function + MODIFY); PN projection is redundant-but-correct.