## DDB1
- **UniProt:** Q16531 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** two rows — (1) `ALP|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Modulator of class 3 PI3K complex 1 activity|Modulator of BECN1 ubiquitination` (all context_only, too_broad: GO:0035032 / GO:0016236); (2) `UPS|E3 ubiquitin and UBL ligases|Cullin adaptor|DDB1` ; **PN-node mapping (UPS):** group "Cullin adaptor"=mapped, ok_for_propagation, **GO:1990756** (substrate-adaptor MF); projected goa_status=more_specific_than_existing_goa.
- **Consistency:** Mostly consistent on biology (central CRL4 adaptor/scaffold; UV-DDB NER; AMBRA1/BECN1 K63 ubiquitination role appears in the description), but a **mapping-category contradiction**: the review correctly classifies DDB1 as a SCAFFOLD and uses GO:0160072 (ubiquitin ligase complex scaffold activity) + GO:0030674 as its core MF, whereas the PN "Cullin adaptor" node maps it to GO:1990756 (substrate-adaptor activity). Those are different MF categories.
- **PN story / NEW pressure:** PN projects GO:1990756 as "more_specific_than_existing_goa," but DDB1's GOA ALREADY contains the correct GO:0160072 (scaffold, IDA) and GO:0030674 (both verified real via OLS); the review ACCEPTs GO:0160072 as core. GO:1990756 (defn: brings ligase together with its SUBSTRATE; F-box/BTB proteins) is biologically wrong for DDB1 — DDB1 bridges CUL4 to DCAF receptors (scaffold), it is not the substrate receptor. Verdict: over-reaches / already captured by the better GO:0160072.
- **Mapping strategy:** This gene SHOULD change the node. DDB1 is the scaffold that the DCAF receptors dock onto; GO:1990756 is the receptor MF. Recommend the "Cullin adaptor"/DDB1 node target GO:0160072, not GO:1990756 (parallels the DDA1 "receptor scaffold" node which correctly uses GO:0160072).
- **Evidence alignment:** Partial. PN UPS refs 19337321 / 19276361 (DCAF-discovery papers) are not individually in the review reference list, though the review cites the cognate DCAF/CUL4-DDB1 framework (PMID:16949367 and many complex-membership PMIDs). PN ALP ref (AMBRA1 review, tandfonline) is not in the review references; the AMBRA1-CRL4-BECN1 story is in the description but not anchored to that PMID.
- **Verdict:** Biology consistent but PN MF mapping mis-categorized. **Recommended edits:** [MAP] retarget DDB1 "Cullin adaptor" node from GO:1990756 to GO:0160072 (scaffold), matching the review's accepted MF and existing GOA.