## DDRGK1
- **UniProt:** Q96HY6 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE (large, well-evidenced review; 60+ annotations)
- **PN placement:** 4 rows across TR/ALP/UPS — `Translation|Cytosolic translation|Ribosome-associated QC|UFMylation`; `ALP|...|ERphagy|UFMylation of ER proteins`; two UPS `...|UFMylation cofactor` rows ; **PN-node mapping:** types mapped to GO:0071569 protein ufmylation and GO:0061709 reticulophagy (ok_for_propagation); RQC group → GO:0006515 protein QC (ok); UPS nodes no_mapping/context_only.
- **Consistency:** Strong agreement. Notes, review, dossier, and projections all converge on DDRGK1 as the obligate ER-membrane UFM1-ligase cofactor / UFM1 reader. Review captures every projected term as an existing annotation (GO:0071569 ufmylation ACCEPT; GO:0061709 reticulophagy KEEP_AS_NON_CORE; ribosome-recycling/RQC via GO:0072344, GO:0032790). No contradictions.
- **PN story / NEW pressure:** The RQC group projects GO:0006515 protein QC as `new_to_goa`. GOA already carries the *specific* RQC outputs GO:0072344 (rescue of stalled cytosolic ribosome) and GO:0032790 (ribosome disassembly), both reviewed. Adding the broad GO:0006515 umbrella would be a less-informative parent of terms already present — over-reaches; the RQC role is **already captured** at greater specificity. GO:0071569 and GO:0061709 are already_in_goa_exact. No defensible NEW term.
- **Mapping strategy:** Mapped status/scope for ufmylation and reticulophagy is correct. The RQC-group → GO:0006515 projection is broader than this gene's reviewed annotations (cf. TOMM20/HSPA8/RAB7A broader-rejection precedent); recommend NOT projecting GO:0006515 onto DDRGK1.
- **Evidence alignment:** Excellent overlap. Dossier ERphagy ref PMID:32160526 and UFMylation-cofactor refs PMID:36121123 / PMID:38383789 are all present, verified, and HIGH-relevance in the review.
- **Verdict:** Consistent and high quality; only the broad GO:0006515 RQC projection over-reaches relative to existing specific GOA terms. **Recommended edits:** [MAP] drop/downgrade GO:0006515 projection for DDRGK1 (specific RQC terms GO:0072344/GO:0032790 already in GOA and reviewed).