## DNAJB4
- **UniProt:** Q9UDY4 (HLJ1/DNAJW) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` (branch CY) ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (parent group/class/branch = no_mapping)
- **Consistency:** Strong agreement. Notes, review YAML and PN annotation all describe a cytosolic class-B HSP40 that stimulates HSP70 (HSPA1A/B) ATPase and delivers misfolded clients. No contradictions; PN "J-domain HSP70 cochaperone" type matches the gene's verified core MF.
- **PN story / NEW pressure:** PN asserts direct HSP70 interaction. This is already captured experimentally: GO:0001671 ATPase activator activity (IDA, PMID:24318877, ACCEPT/core) and GO:0051087 protein-folding chaperone binding (IPI PMID:21231916, ACCEPT/core). The PN-projected GO:0030544 "Hsp70 protein binding" (verified real via OLS) is a child of GO:0051087 — i.e. it would be a *more specific* refinement, not a missing function. No NEW-term pressure; the muscle/Z-disc role (GO:0030018 IDA) is also well captured. Verdict: already captured (GO:0030544 is a defensible specialization).
- **Mapping strategy:** Node already mapped to GO:0030544 (correct, narrower than the gene's GO:0051087). Status/scope appropriate — DNAJB4 has direct IPI HSP70-binding evidence, so it genuinely supports the type-level mapping rather than over-reaching. Parent no_mapping decisions are sound.
- **Evidence alignment:** PN reference titles overlap the review's core PMIDs (21231916 HSP70 machine; 24318877 NEF/ATPase; 36264506 myopathy/Z-disc). No divergence.
- **Verdict:** CONSISTENT — PN GO:0030544 is a defensible narrower specialization of the gene's experimentally-supported GO:0051087/GO:0001671 HSP70-cochaperone MF; node mapping correct.