## DNAJB5
- **UniProt:** O75953 (Hsc40) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` (branch CY) ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (parents no_mapping)
- **Consistency:** Consistent but note the weaker evidence base. Notes/YAML stress DNAJB5 is poorly characterized: it is a cytosolic class-B J-protein whose HSP70 binding rests on GOA GO:0051087 IPI (PMID:21231916) and family inference, with NO direct ATPase-stimulation data. The review correctly does NOT assert GO:0001671 as core (unlike DNAJB4). PN "J-domain HSP70 cochaperone" type is consistent with the available (family/IPI-level) evidence.
- **PN story / NEW pressure:** PN asserts HSP70 interaction — captured by GO:0051087 (IPI PMID:21231916 + IBA/IEA, ACCEPT/core). PN-projected GO:0030544 (verified real) is a child of GO:0051087, so it is a more-specific refinement, defensible from the same IPI-to-HSP70 evidence. No NEW-term pressure. A possible muscle/titin role (PMID:23414517) is flagged in notes but explicitly not functionally demonstrated — correctly left as non-core. Verdict: already captured.
- **Mapping strategy:** Mapping to GO:0030544 is appropriate; scope ok_for_propagation given the IPI HSP70 anchor. Because DNAJB5 lacks its own holdase/ATPase data, the type-level (rather than over-broad "unfolded protein binding") mapping is the right altitude — does not over-reach.
- **Evidence alignment:** Shared anchor PMID:21231916 (HSP70 machine). Review adds HT-interactome PMIDs (titin, CACNA1A, EBNA-LP) absent from PN; PN adds nothing the review lacks.
- **Verdict:** CONSISTENT — GO:0030544 defensible as narrower than the gene's GO:0051087; correct that no ATPase/holdase MF is asserted for this poorly-characterized member.