## DNAJC10
- **UniProt:** Q8IXB1 (ERdj5) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** row1 `ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` (GO:0030544); row2 `ER proteostasis|Folding enzyme|Protein disulfide isomerases` (group=mapped GO:0003756 protein disulfide isomerase activity, `new_to_goa`)
- **Consistency:** Row1 is fully consistent — review and notes confirm J-domain binding of BiP/HSPA5 and GO:0030544 is in GOA (`already_in_goa_exact` is correct). Row2 contains a mechanistic contradiction: PN files ERdj5 under "Protein disulfide isomerases" and projects GO:0003756 (PDI = isomerase activity), but the review, notes, UniProt (RecName "ER disulfide reductase"), and literature (PMID:23769672, PMID:37739037) establish ERdj5 as a disulfide **reductase** (GO:0015035, EC 1.8.4.2), not an isomerase. The review correctly annotates reductase activity and never asserts GO:0003756.
- **PN story / NEW pressure:** GO:0003756 is a verified real term but sits in the isomerase branch (GO:0016853 → GO:0016864 transposing S-S bonds), whereas GO:0015035 is in the oxidoreductase branch (GO:0016491). They are mechanistically distinct. ERdj5 removes/reduces non-native disulfides; it does not rearrange them. Projecting GO:0003756 onto DNAJC10 over-reaches and is the wrong activity. The correct, already-captured term is GO:0015035 (IDA, in GOA).
- **Mapping strategy:** Row2 group mapping should be reconsidered for ERdj5 — the "Protein disulfide isomerases" PN group conflates reductases with isomerases. For DNAJC10 specifically the propagated term should be GO:0015035 (protein-disulfide reductase activity), not GO:0003756.
- **Evidence alignment:** PN row carries no titles; review evidence (PMID:12411443, 18400946, 23769672, 37739037 — all verified) uniformly supports reductase + BiP co-chaperone, none supports isomerase activity. Divergence is in the PN group label, not the literature.
- **Verdict:** Row1 consistent/captured; Row2 over-reaches (PDI isomerase ≠ ERdj5 reductase). **Recommended edits:** [MAP] retarget DNAJC10 row2 from GO:0003756 (PDI activity) to GO:0015035 (protein-disulfide reductase activity), or exclude ERdj5 from the "Protein disulfide isomerases" PN group as a reductase exception.