## DNAJC12
- **UniProt:** Q9UKB3 (JDP1) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (group/class/branch = no_mapping)
- **Consistency:** Consistent on the J-domain axis. Review, notes, and PN agree DNAJC12 is a cytosolic J-domain-only HSP70 co-chaperone that binds Hsc70/HSPA8 and stimulates HSP70 ATPase. The review MODIFIES the bare GO:0005515 (HSPA8 interaction, PMID:24122553) to GO:0030544, matching the PN projection exactly. No contradiction. The disease-defining specific-client role (chaperone for aromatic amino acid hydroxylases PAH/TH/TPH; PMID:28132689) is captured in the review's core_functions but is outside the single PN row.
- **PN story / NEW pressure:** GO:0030544 is verified real and is the right target. GOA currently has only GO:0005515 + GO:0005737, so relative to GOA this is effectively `new_to_goa`, not `more_specific_than_existing_goa` as the PN label states (no GO:0031072 parent in GOA) — a minor status-label inaccuracy. The hydroxylase-chaperone biology is the gene's distinctive story but there is no specific "aromatic amino acid hydroxylase binding" GO term; it is appropriately rendered via GO:0051087 (protein-folding chaperone binding) in core_functions. No NEW term warranted.
- **Mapping strategy:** Node mapping is appropriate; DNAJC12 is a genuine HSP70 cochaperone and GO:0030544 is a defensible, suitably narrow propagation. The review already realizes it (MODIFY), so propagation would be confirmatory.
- **Evidence alignment:** PN row carries no titles; review anchors on PMID:24122553 (Hsc70 binding, verified) and PMID:28132689 (HSP70 cochaperone of hydroxylases, verified). No divergence.
- **Verdict:** Consistent; PN GO:0030544 defensible and already realized in the review. **Recommended edits:** [MAP] (minor) correct DNAJC12 projected `goa_status` from `more_specific_than_existing_goa` to `new_to_goa` (GOA lacks the GO:0031072 parent).