## DNAJC13
- **UniProt:** O75165 (RME-8) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (group/class/branch = no_mapping)
- **Consistency:** Partial. PN frames DNAJC13 purely as a J-domain HSP70 cochaperone (GO:0030544). The review and notes agree it is an HSC70/HSPA8 co-chaperone whose internal J domain stimulates HSC70 ATPase to drive endosomal clathrin dynamics — so the cochaperone identity is consistent — but the review's center of gravity is the endosomal sorting biology (GO:0007032 endosome organization, GO:2001135, GO:2000641, GO:0071203 WASH complex). Notably the review chose GO:0001671 (ATPase activator activity) for core_functions, NOT GO:0030544, and GOA contains neither. So the specific Hsp70-binding claim is inferred, not directly annotated.
- **PN story / NEW pressure:** GO:0030544 is verified real. Relative to GOA (which has only bare GO:0005515 for protein binding among MF terms) this is `new_to_goa`, not `more_specific_than_existing_goa` as the PN label states. The cochaperone MF is biologically defensible (J domain + HSC70 binding, conserved from C. elegans), so GO:0030544 is a reasonable ADD — but the review's preferred GO:0001671 (ATPase activator activity) is the complementary/arguably more mechanistic MF. The distinctive endosomal-sorting biology is already well captured; no further NEW term needed.
- **Mapping strategy:** Node mapping is acceptable for the cochaperone MF, but for DNAJC13 the propagated term arguably should pair GO:0030544 with GO:0001671 (the review's choice). The J domain is internal/non-canonical, but the cochaperone role is real, so this is not an over-reach like DNAJC11.
- **Evidence alignment:** PN carries no titles; review anchors on PMID:18256511, 18307993, 24643499 (all verified) — endosomal/WASH/SNX1, none directly demonstrating Hsp70 binding (the cochaperone MF rests on UniProt + orthology). Divergence: PN emphasizes the (inferred) Hsp70 MF; literature emphasizes endosomal function.
- **Verdict:** Cochaperone identity consistent; GO:0030544 defensible but inferred. **Recommended edits:** [MAP] (minor) correct DNAJC13 projected `goa_status` to `new_to_goa`; optionally co-propagate GO:0001671 (ATPase activator activity) to match the review's core MF.