## DNAJC14
- **UniProt:** Q6Y2X3 (DRIP78) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (group/class/branch = no_mapping)
- **Consistency:** Tension. PN projects GO:0030544 (Hsp70 binding) as the cochaperone MF. The review and notes describe DNAJC14 as a multi-pass ER-membrane J-protein whose documented function is GPCR ER-export chaperoning (binds DRD1 via FxxxFxxxF motif); the review's core MF is GO:0050780 (dopamine receptor binding) / GO:0001664 (GPCR binding). The review explicitly states the J-domain HSP70-cochaperone activity is **inferred but the functional readout is GPCR ER export** and there is no cached experimental human paper for a direct HSP70 interaction. GOA contains no GO:0030544 or GO:0031072. So PN's Hsp70-binding claim is unverified for this gene.
- **PN story / NEW pressure:** GO:0030544 is verified real but, for DNAJC14, asserts an HSP70 interaction that is neither in GOA nor experimentally cited — the review even lists "does DNAJC14 recruit an ER HSP70" as an open suggested_question. This is over-broad J-domain inference. The gene's actual, supported biology (dopamine/GPCR receptor binding, ER export) is captured (GO:0050780, GO:0001664). No defensible NEW Hsp70 term; the cochaperone MF here is speculative.
- **Mapping strategy:** Propagating GO:0030544 to DNAJC14 over-states the evidence (parallel to DNAJC11/DNAJC13 but weaker still — no demonstrated ATPase activator role either). Better to leave DNAJC14's propagating MF as its receptor-binding / ER-export terms and treat the HSP70-cochaperone assignment as unverified.
- **Evidence alignment:** PN carries no titles; review evidence is UniProt (by similarity) + IBA/IEA for DRD1/GPCR binding (PMID:11331877 cited in notes, not GOA; PMID:19946888 only for membrane). No paper supports direct Hsp70 binding. Divergence from PN cochaperone framing.
- **Verdict:** PN over-reaches — Hsp70 binding unverified; DNAJC14's supported function is GPCR ER export. **Recommended edits:** [MAP] do not propagate GO:0030544 to DNAJC14 (mark cochaperone MF unverified); retain GO:0050780 / GO:0001664 as the gene-level MF.