## DNAJC15
- **UniProt:** Q9Y5T4 (MCJ) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Mitochondrial proteostasis | Chaperone | HSP70 system | J-domain containing HSP70 cochaperone` (branch MI) ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (goa_status=more_specific_than_existing_goa)
- **Consistency:** Strong agreement. Deep-research notes, review YAML and PN node all converge on a TIM23/PAM J-domain co-chaperone that stimulates matrix HSP70 (mortalin/HSPA9). No contradictions. The review additionally documents a second, mitochondrial-import-independent role (negative regulation of respiratory chain/complex I, PMID:23530063) that the PN single-row mapping does not represent, but this is a coverage gap, not a contradiction.
- **PN story / NEW pressure:** PN asserts the generic co-chaperone "Hsp70 protein binding". The review captures the function more precisely as GO:0001671 ATPase activator activity (experimentally demonstrated mortalin stimulation, PMID:23263864). GO:0030544 (verified real via OLS; child of GO:0031072/GO:0051087) is biologically true for MCJ but is NOT a parent of GO:0001671 — it is a different (binding vs activator) MF axis, and is broader/less informative than what the review already records. Not an ADD: the binding is real but the activator-activity annotation already exists and is superior.
- **Mapping strategy:** No change to the node warranted from this gene. The "more_specific_than_existing_goa" tag is inaccurate here — GO:0030544 is not more specific than the existing GO:0001671 ATPase activator activity; it is an orthogonal/broader label. The respiratory-chain repressor role is genuinely outside the HSP70-cochaperone node and should not be forced into it.
- **Evidence alignment:** Excellent overlap. Both rest on PMID:23263864 (Schusdziarra 2013, import co-chaperone) plus PMID:23530063 (Hatle 2013, respiratory repressor) in the review. PN reference titles match the import-cochaperone framing.
- **Verdict:** Consistent; PN projection (Hsp70 binding) is true but already captured more informatively (ATPase activator activity). No edits required.