## DNAJC19
- **UniProt:** Q96DA6 (TIM14/TIMM14) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Mitochondrial proteostasis | Chaperone | HSP70 system | J-domain containing HSP70 cochaperone` (branch MI) ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (goa_status=more_specific_than_existing_goa)
- **Consistency:** Strong agreement. Notes, review and PN node all describe the prototypical TIM23/PAM J-protein that stimulates matrix HSP70 (mortalin/HSPA9). Experimentally established for the human protein (PMID:20053669: ~70% ATPase stimulation in the Magmas:DnaJC19 complex; PMID:19564938). No contradictions. This is the best-supported member of the six (vs DNAJC15's PAM18-orthologue role; correctly distinguished as the genuine TIM23-associated import J-protein).
- **PN story / NEW pressure:** PN proposes GO:0030544 Hsp70 protein binding (verified real). The binding is genuine (DNAJC19 directly engages/stimulates mortalin), but the review already records the stronger, more informative GO:0001671 ATPase activator activity (experimentally supported). GO:0030544 is NOT a parent of GO:0001671 — it is the binding axis, broader/less informative than the existing activator-activity annotation. Not an ADD; the function is already captured better.
- **Mapping strategy:** No node change warranted. As with DNAJC15, "more_specific_than_existing_goa" is inaccurate — GO:0030544 is not more specific than the existing GO:0001671 ATPase activator activity. The secondary cardiolipin/prohibitin role (ISS, GO:1900208) sits outside this node and is correctly non-core in the review.
- **Evidence alignment:** Excellent overlap on the import-motor biology. Review anchors on PMID:20053669 and PMID:19564938 (both VERIFIED) plus the DCMA disease paper PMID:16055927 (UNVERIFIED, uncached). PN reference titles align with the J-domain/Hsp70-stimulation framing.
- **Verdict:** Consistent and well-supported; PN's Hsp70-binding projection is true but already captured more informatively (ATPase activator activity). No edits required.