## DNAJC25
- **UniProt:** Q9H1X3 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (projected new_to_goa); group/class/branch=no_mapping.
- **Consistency:** Deep research, notes, and review YAML agree: DNAJC25 is a poorly characterized multi-pass membrane DnaJ/HSP40 protein with an HPD-bearing J-domain; no direct human functional data. Review core MF = GO:0031072 heat shock protein binding (family/domain inference). PN "J-domain HSP70 cochaperone" placement is consistent. No contradictions; both flag the inference-only basis.
- **PN story / NEW pressure:** PN asserts GO:0030544 Hsp70 protein binding (verified real). GOA lacks it (new_to_goa correct). GO:0030544 is a child of the review's GO:0031072 (heat shock protein binding) via GO:0051087 — i.e. PN proposes a strictly MORE SPECIFIC term than the review. Defensible as a J-protein domain-level inference, but rests on the same predicted-only evidence; an ADD as an inferred MF is reasonable but should not be over-elevated given zero experimental support for the human protein.
- **Mapping strategy:** Node status unchanged. Projection accurate (term absent from GOA). PN term is NARROWER than the review's core MF — appropriate direction for a J-domain protein, no over-broad inference concern.
- **Evidence alignment:** PN row has no reference titles; review cites only the UniProt file (no primary literature exists). No divergence, but evidence base is thin on both sides.
- **Verdict:** Consistent. GO:0030544 ADD defensible as domain-inferred MF (new_to_goa, narrower than review's GO:0031072); keep IBA-strength caveat.