## DNAJC30
- **UniProt:** Q96LL9 (WBSCR18) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` ; **PN-node mapping:** type=mapped, scope=ok_for_propagation_to_go, GO:0030544 Hsp70 protein binding (projected more_specific_than_existing_goa); group/class/branch=no_mapping (class explicitly "too heterogeneous").
- **Consistency:** SUBSTANTIVE TENSION. Deep research and review YAML establish DNAJC30 as a mitochondrial inner-membrane factor with two well-supported, NON-canonical-chaperone roles: (1) auxiliary component of ATP synthase (direct MT-ATP6/ATP5MC2 binding, PMID:30318146; core MF GO:0019899 enzyme binding); (2) chaperone in **complex I N-module repair/subunit exchange** (PMID:33465056; core MF GO:0051082 unfolded protein binding; causes recessive LHON). The review explicitly does NOT establish any HSP70 interaction. The PN "J-domain HSP70 cochaperone" placement is an over-broad family inference: DNAJC30 is a complex-I assembly/repair factor, not a characterized HSP70 cochaperone.
- **PN story / NEW pressure:** PN asserts GO:0030544 Hsp70 protein binding (verified real) — but this is contradicted in emphasis by the review, which found no HSP70 partner (the J-domain's canonical cochaperone activity is itself flagged as an open question in suggested_questions). GOA has no chaperone-binding term, so "more_specific_than_existing_goa" is wrong; at most new_to_goa, and even as new it OVER-REACHES given the characterized complex-I/ATP-synthase biology. Mirrors the TOMM20/HSPA8/RAB7A "rejected as broader/family-inferred" precedent.
- **Mapping strategy:** This gene argues AGAINST propagating GO:0030544 from the type node to DNAJC30. The review's evidence-backed MFs (GO:0051082, GO:0019899) are the right calls; the family-projected GO:0030544 is broader/unsupported for this member.
- **Evidence alignment:** PN row no titles; review cites PMID:30318146 (ATP synthase/brain dev) and PMID:33465056 (complex I repair / recessive LHON) — both VERIFIED, full-text cached. No paper supports HSP70 binding.
- **Verdict:** Over-reach. GO:0030544 projection is unsupported for DNAJC30 (a complex-I repair / ATP-synthase auxiliary factor). **Recommended edits:** [MAP] do not propagate GO:0030544 to DNAJC30 (family-level over-inference; gene-level GO:0051082 + GO:0019899 already capture its biology); [MAP] if retained, downgrade goa_status to new_to_goa and mark as IBA/family-inferred only.