## DNAJC5
- **UniProt:** Q9H3Z4 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` (branch ER) ; **PN-node mapping:** type → mapped/ok_for_propagation_to_go GO:0030544 Hsp70 protein binding (goa_status=more_specific_than_existing_goa); all ancestor nodes no_mapping.
- **Consistency:** Strongly consistent on MF, with one placement nuance. Deep research (notes), review and PN converge on DNAJC5/CSPalpha as a palmitoylated J-domain co-chaperone of HSC70/HSPA8 (the SNAP-25 co-chaperone with SGTA) at the synaptic/secretory vesicle membrane; CLN4 disease gene (PMID:21820099). The review's core MF is exactly GO:0030544 Hsp70 protein binding (it even MODIFIES the rat-ortholog GO:0043008 ATP-dependent protein binding → GO:0030544), matching the PN projection. Nuance: PN places CSPalpha in the **ER** branch, whereas the dominant biology (and the review's core localizations: synaptic vesicle membrane, presynapse) is synaptic/secretory — not ER. The secretory-vesicle/exocytic role is ER-branch-adjacent (secretory pathway), so this is a reasonable umbrella, not a contradiction.
- **PN story / NEW pressure:** GO:0030544 is already the review's core MF, so the PN story is **already captured** (and verified real). No NEW pressure; CSPalpha's specific synaptic CSP role (regulation of synaptic vesicle cycle, synaptic vesicle exocytosis) is well annotated and goes beyond the generic J-domain MF the PN node carries.
- **Mapping strategy:** No change to the node. GO:0030544 is the correct, defensible Hsp70-cochaperone MF (not an over-broad holdase claim). goa_status=more_specific_than_existing_goa is accurate (GOA had only the broader/ATP-dependent terms).
- **Evidence alignment:** PN carries no row references. Review cites the disease/mechanism literature (PMID:21820099, 10099709, 15217342, 17081065, 29997244, 33961781) plus Reactome rows; well-supported, no divergence from PN.
- **Verdict:** Fully consistent; PN Hsp70-binding story already captured as core MF (GO:0030544). **Recommended edits:** none required; optionally [MAP] note that CSPalpha is the prototypical *synaptic/secretory-vesicle* CSP, so the ER-branch placement is an umbrella rather than its primary compartment.