## DNAJC5B
- **UniProt:** Q9UF47 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` (branch ER) ; **PN-node mapping:** type → mapped/ok_for_propagation_to_go GO:0030544 Hsp70 protein binding (goa_status=more_specific_than_existing_goa); all ancestor nodes no_mapping.
- **Consistency:** Consistent. Deep research (notes), review and PN converge on DNAJC5B/CSP-beta as a testis-specific CSPalpha paralog (J domain aa 19-84) that interacts with the HSC70-SGTA chaperone complex and targets the trans-Golgi network as a non-palmitoylated CSP (PMID:17034881, Boal et al.). The review's core MF is exactly GO:0030544 Hsp70 protein binding, matching the PN projection. The TGN/secretory-pathway context makes the ER-branch placement reasonable. The HSC70/SGTA interaction is experimentally documented (not just family inference), so GO:0030544 here is better-supported than for the Tdark paralogs DNAJC4/DNAJC5G.
- **PN story / NEW pressure:** GO:0030544 is already the review's core MF → **already captured** (verified real). goa_status=more_specific_than_existing_goa is accurate (GOA had no chaperone-binding MF, only membrane/cytoplasm + one HT protein-binding IPI with TFCP2). The Hsp70-cochaperone assertion is genuine MF (the experimental HSC70-SGTA interaction), not an over-broad holdase claim.
- **Mapping strategy:** No change to the node. GO:0030544 is the correct breadth and is experimentally anchored for this gene.
- **Evidence alignment:** PN carries no row references. Review cites PMID:17034881 (HIGH relevance, UNVERIFIED/uncached primary functional paper) and PMID:25416956 (proteome-scale Y2H, TFCP2 HT hit). No divergence from PN.
- **Verdict:** Fully consistent; PN Hsp70-binding story already captured as core MF and experimentally supported via HSC70/SGTA. **Recommended edits:** none required.