## DNAJC6
- **UniProt:** O75061 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone` (branch CY) ; **PN-node mapping:** type → mapped/ok_for_propagation_to_go GO:0030544 Hsp70 protein binding (goa_status=more_specific_than_existing_goa); all ancestor nodes no_mapping.
- **Consistency:** Consistent, with one MF-specificity nuance. Deep research (notes), review and PN converge on DNAJC6/auxilin as the neuronal clathrin-uncoating co-chaperone: binds clathrin cages (1 per triskelion) and, via its C-terminal J domain, recruits HSPA8/HSC70 and stimulates its ATPase to dismantle the coat; PARK19 disease gene (PMID:18489706 VERIFIED, 20160091 VERIFIED, 29735704). The review's chaperone-binding core MF is GO:0031072 heat shock protein binding (ISS, ACCEPT) plus clathrin binding/clathrin heavy chain binding (GO:0030276/GO:0032050). PN projects the **narrower** GO:0030544 Hsp70 protein binding — and since auxilin binds specifically HSPA8/HSC70 (an Hsp70), GO:0030544 is in fact MORE accurate than the review's GO:0031072; GOA currently has only GO:0031072. (GO:0030544 is_a GO:0031072.)
- **PN story / NEW pressure:** GO:0030544 (verified real) is not yet in GOA or the review (which uses the parent GO:0031072). This is a legitimate **ADD** / refinement: auxilin's documented partner is HSPA8/HSC70, so the specific Hsp70 protein binding term is defensible and more informative. goa_status=more_specific_than_existing_goa is exactly right.
- **Mapping strategy:** No change to node breadth. Unlike rejected broad cases (TOMM20/HSPA8/RAB7A), here the PN projection is *narrower and more specific* than existing GOA/review and is well-supported — a genuine refinement, not an over-reach.
- **Evidence alignment:** PN carries no row references. Review/notes cite the verified uncoating literature (PMID:18489706, 20160091) + CLTC/LRRK2 (PMID:29735704). Strong, no divergence from PN.
- **Verdict:** Consistent and well-supported; PN's GO:0030544 is a defensible more-specific ADD over the review/GOA's GO:0031072. **Recommended edits:** [YAML][MAP] consider replacing/supplementing GO:0031072 heat shock protein binding with the more specific GO:0030544 Hsp70 protein binding in the review core MF (auxilin's documented partner is HSPA8/HSC70), aligning with the PN projection.