## DNAJC7
- **UniProt:** Q99615 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** two rows — row1 `Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone`; row2 `Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and J domain containing` (branch CY) ; **PN-node mapping:** row1 type → mapped/ok GO:0030544 Hsp70 protein binding (more_specific_than_existing_goa); row2 subtype → no_mapping, type → mapped/ok GO:0031072 heat shock protein binding (already_in_goa_exact); ancestors no_mapping.
- **Consistency:** Fully consistent and the most richly supported of the set. Deep research (notes), review and PN converge on DNAJC7/Tpr2: dual TPR clusters + C-terminal J domain that binds HSP70 and HSP90 simultaneously and, via its J domain, stimulates HSP70 ATPase, mediating retrograde HSP90→HSP70 substrate transfer (PMID:12853476 VERIFIED, 18620420 VERIFIED); ALS risk gene. Review core MFs are GO:0001671 ATPase activator activity and GO:0031072 heat shock protein binding (both ACCEPT) — exactly matching PN row2's GO:0031072 (already_in_goa_exact, confirmed in GOA). PN row1 additionally projects GO:0030544 Hsp70 protein binding (narrower); GOA has the parent GO:0031072 but not GO:0030544.
- **PN story / NEW pressure:** Row2 already captured (GO:0031072 = review core MF, in GOA). Row1's GO:0030544 (verified real) is a more-specific ADD candidate: Tpr2's TPR domains bind both HSP70 *and* HSP90, so the broader GO:0031072 (which the review correctly chose for the *dual* HSP70/HSP90 binding) is arguably the better umbrella; GO:0030544 captures only the HSP70 arm. Defensible as a supplementary ADD but the existing GO:0031072 better reflects the joint HSP70/HSP90 cochaperone biology. The ATPase-activator MF (GO:0001671) is the strongest core call and is captured by the review but NOT projected by either PN node.
- **Mapping strategy:** Two-row treatment is correct (J-domain HSP70 system + HSP70-HSP90 integration). Neither node over-reaches. The PN's two-node split appropriately distinguishes the J-domain HSP70 role from the TPR-mediated HSP70/HSP90 bridging role.
- **Evidence alignment:** PN carries no row references. Review cites verified mechanistic literature (PMID:12853476, 18620420, 11573955, 8836031) + many HT IPI rows; no divergence from PN.
- **Verdict:** Fully consistent; row2 already captured, row1 GO:0030544 a defensible-but-secondary more-specific ADD. **Recommended edits:** [MAP] note that for DNAJC7 the broader GO:0031072 (joint HSP70/HSP90 binding) is the better umbrella than the HSP70-only GO:0030544; consider also projecting the well-supported GO:0001671 ATPase activator activity (review core MF, in GOA) from the J-domain node.