## DRG2
- **UniProt:** P55039 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** type `other RQC processes` no_mapping; group `Ribosome-associated QC` → GO:0006515 protein QC (mapped, ok_for_propagation); class/branch context_only.
- **Consistency:** Review and notes are consistent with each other (DRG2 = TRAFAC/OBG-family translational GTPase; core MF GO:0003924 GTPase activity; JMJD7-hydroxylation/RNA-binding context; DFRP2/RWDD1 cofactor). They are NOT consistent with the PN placement: nothing in the review, notes, or GOA establishes DRG2 as a ribosome-associated quality-control / surveillance factor. The review even keeps the broad GO:0002181 cytoplasmic translation as non-core because "the specific regulatory role of human DRG2 in translation is not precisely defined."
- **PN story / NEW pressure:** Dossier projects GO:0006515 protein QC as `new_to_goa`. No evidence (GOA has GO:0002181 + GO:0003924 only; no QC/RQC/rescue terms) supports DRG2 as an RQC factor. Asserting GO:0006515 would be an unsupported functional claim, not merely a broad umbrella — **over-reaches**. No defensible NEW term; if anything the gene is at most a generic ribosome-associated GTPase.
- **Mapping strategy:** This gene weakens the `Ribosome-associated QC` group → GO:0006515 mapping: DRG2's membership in "other RQC processes" looks like taxonomic placement of a ribosome-associated GTPase rather than a demonstrated QC role. Recommend NOT projecting GO:0006515 onto DRG2 (no QC evidence).
- **Evidence alignment:** Dossier provides no reference titles. Review anchors are PMID:29915238 (JMJD7/GTPase, VERIFIED) and PMID:7929244 (original cloning, VERIFIED) — both about GTPase identity, neither about RQC. Divergence: dossier RQC framing has no supporting citation.
- **Verdict:** GTPase biology is solid, but the PN RQC placement and GO:0006515 projection are unsupported for DRG2. **Recommended edits:** [MAP] do not project GO:0006515 (protein QC) to DRG2 — no RQC/surveillance evidence; GTPase activity (GO:0003924) is the supported core.