## DTL
- **UniProt:** Q9NZJ0 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other` ; **PN-node mapping:** group "Cul4A/Cul4B substrate receptor"=mapped, ok_for_propagation, GO:1990756 (substrate-adaptor MF); subtype/type=no_mapping; projected GO:1990756 goa_status=more_specific_than_existing_goa.
- **Consistency:** Consistent on biology — DTL/CDT2 is the DCAF substrate receptor of CRL4(CDT2), recruiting PCNA-bound PIP-degron substrates (CDT1, p21, SET8, FBH1, SDE2). Divergence only in MF vocabulary: review uses GO:0030674 (protein-macromolecule adaptor activity, ACCEPTed from GOA IBA) for all three core functions; PN projects GO:1990756.
- **PN story / NEW pressure:** PN projects GO:1990756 as "more_specific_than_existing_goa." GOA already has GO:0030674 (enables, IBA) and GO:0004842 (contributes_to) — confirmed in goa.tsv; GO:1990756 is NOT in GOA. GO:1990756 (verified real; F-box/BTB receptor MF) is indeed more specific than the generic GO:0030674 for a CRL substrate receptor. Verdict: defensible ADD (more specific), but the reviewer deliberately preferred GO:0030674 as the receptor MF; this is a vocabulary judgment, not a substantive disagreement.
- **Mapping strategy:** Correct category — DTL is a genuine DCAF substrate receptor, so GO:1990756 (receptor) is well placed (contrast DDB1, which is scaffold). Node status/scope appropriate; narrower than existing generic GOA.
- **Evidence alignment:** PN row lists no references; the review is well-evidenced (PMID:16949367 Cdt1 destruction; 18794347 p21 recruitment; 17085480 G2/M checkpoint IMP; 20129063 PCNA K164 monoubiquitination). No conflict; PN under-cites.
- **Verdict:** Consistent; PN GO:1990756 is correctly categorized and a defensible more-specific add over the review's GO:0030674. **Recommended edits:** [YAML] optionally add/swap GO:1990756 as the DCAF substrate-receptor MF (more specific than GO:0030674), aligning with the PN projection.