## EDEM1
- **UniProt:** Q92611 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming` ; **PN-node mapping:** subtype "Mannose trimming"=mapped/ok GO:1904382 (mannose trimming in glycoprotein ERAD, `already_in_goa_exact`); group "N-glycosylation system"=mapped/ok GO:0006487 protein N-linked glycosylation (`new_to_goa`); intermediate type/class/branch=no_mapping.
- **Consistency:** Deep research ↔ review YAML ↔ PN annotation consistent. EDEM1 = GH47 type-II ER membrane factor that recognizes terminally misfolded glycoproteins (glycan-independently) and delivers them to SEL1L/HRD1 ERAD; possesses weak alpha-1,2-mannosidase activity (second step Man8B→Man7). Critically, the **negated** (NOT) GO:0004571 IDA from PMID:12610306 (historical "no activity") is correctly retained as superseded by the positive IMP GO:0004571 (PMID:25092655). Review and notes both flag this NOT-vs-positive tension explicitly. No contradictions.
- **PN story / NEW pressure:** PN's mannose-trimming subtype → GO:1904382, which is `already_in_goa_exact` (TAS Reactome + matches review). EDEM1's contribution is already captured (GO:1904380, GO:1904382, GO:0036503, GO:0004571 IMP). No NEW term needed; review proposes none. Already captured.
- **Mapping strategy:** subtype→GO:1904382 is exact and well-supported — keep. **Caveat on the catalytic MF:** EDEM1 is catalytic but WEAKLY so (weakest of the three EDEMs); the review correctly keeps GO:0004571 as a supporting (not dominant) function behind GO:0051787 misfolded protein binding (its defining CORE MF). The group→GO:0006487 protein N-linked glycosylation projection is broader/upstream (glycan installation) than EDEM1's degradative trimming role and is a loose fit — borderline over-reach for a degradation-arm factor.
- **Evidence alignment:** Strong overlap on the shared landmark PMID:25092655 (also EDEM2/EDEM3) and Reactome:R-HSA-6782685. Review adds extensive EDEM1-specific literature (PMID:12610306, 19524542, 21062743, 23233672, 24200403, 30374462, 32423001) beyond the PN row.
- **Verdict:** Consistent and well-curated; NOT-mannosidase tension handled correctly. subtype→GO:1904382 sound; group→GO:0006487 is a loose/broad fit for the degradation arm.