## EEF2K
- **UniProt:** O00418 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Translation elongation|assorted elongation factors` ; **PN-node mapping:** type `assorted elongation factors` → GO:0003746 translation elongation factor activity (mapped, ok_for_propagation); group `Translation elongation` → GO:0006414 context_only.
- **Consistency:** Internal review/notes are consistent and correct: EEF2K is a Ca2+/calmodulin-dependent **alpha-kinase** whose sole substrate is eEF2 (core MF GO:0004686 elongation factor-2 kinase activity). This DIRECTLY CONTRADICTS the PN node, which files EEF2K among "elongation factors" and projects GO:0003746 translation elongation factor activity. EEF2K is the regulatory kinase, not an EF. The review even REMOVES GO:0008135 (translation factor activity, RNA binding) as a substrate-conflation error — the same conflation the PN projection makes.
- **PN story / NEW pressure:** Projected GO:0003746 is `more_specific_than_existing_goa` per dossier, but it is the wrong molecular function for this gene. EEF2K's function is already captured by GO:0004686 (in GOA, ACCEPTed core) and would be better served at the process level by GO:0045900 negative regulation of translational elongation (OLS-verified; already the review's MODIFY target for GO:0006414). The PN term **over-reaches / is wrong**.
- **Mapping strategy:** EEF2K argues the `assorted elongation factors` type conflates true EFs (eEF1A/eEF2) with elongation *regulators*. Projecting GO:0003746 onto a kinase is a category error; recommend excluding kinases/regulators from that type's MF projection.
- **Evidence alignment:** Dossier gives no reference titles. Review anchors PMID:9144159 (alpha-kinase founding paper), PMID:11015200, PMID:23184662 — all VERIFIED and about kinase activity, none supporting EF activity. Divergence: PN node has no citation backing an EF role.
- **Verdict:** Clear mis-mapping — EEF2K is the eEF2 kinase, not a translation elongation factor; GO:0003746 should not be projected. **Recommended edits:** [MAP] remove GO:0003746 projection for EEF2K; if a shared process is wanted use GO:0045900 negative regulation of translational elongation. Core MF GO:0004686 already in GOA.