## EIF2D
- **UniProt:** P41214 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Translation termination|tRNA, mRNA release` ; **PN-node mapping:** group `Translation termination` → GO:0006415 translational termination (mapped, ok_for_propagation); type `tRNA, mRNA release` no_mapping.
- **Consistency:** Review/notes are accurate and self-consistent: EIF2D (Ligatin) is the single-polypeptide eIF2D-like factor that does GTP-independent P-site tRNA delivery and post-termination **40S recycling/reinitiation** (core MF GO:0003743). This CONTRADICTS the PN "Translation termination" placement and GO:0006415 projection — EIF2D is not a release factor. (Same node mis-classification as DENR, its split-paralog partner.)
- **PN story / NEW pressure:** Projected GO:0006415 translational termination is `more_specific_than_existing_goa`. Verified (OLS): GO:0006415 = polypeptide release at a stop codon — not EIF2D's activity. EIF2D's real roles (GO:0001731 preinitiation-complex formation, GO:0032790 ribosome disassembly/recycling, GO:0003743 initiation-factor activity) are **already in GOA** and reviewed. The projection **over-reaches / is biologically wrong**; no defensible NEW termination term.
- **Mapping strategy:** Reinforces the DENR finding: the `Translation termination|tRNA, mRNA release` node lumps post-termination recycling/reinitiation factors (EIF2D, DENR) with genuine release factors. Recommend re-homing EIF2D under reinitiation/40S-recycling and not propagating GO:0006415.
- **Evidence alignment:** Dossier carries no reference titles. Review anchors PMID:20566627 (GTP-independent P-site tRNA delivery) and PMID:20713520 (Ligatin recycling), both VERIFIED — about initiation/recycling, none about termination. Divergence by omission in dossier.
- **Verdict:** Mapping mismatch — PN "translation termination" + GO:0006415 contradicts EIF2D's initiation/recycling biology already in GOA. **Recommended edits:** [MAP] do not project GO:0006415 to EIF2D; reclassify PN node toward reinitiation/40S recycling (GO:0001731 / GO:0032790 already in GOA).