## EIF3J
- **UniProt:** O75822 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** 2 rows — `Translation|Cytosolic translation|Translation initiation|eIF3 complex` and `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** initiation type → GO:0005852 eIF3 complex (mapped); initiation group → GO:0006413 translational initiation (mapped); RQC group → GO:0006515 protein QC (mapped, new_to_goa); RQC type no_mapping.
- **Consistency:** Initiation row is fully consistent — review accepts GO:0005852 (core CC) and GO:0006413 (core BP), both in GOA. The RQC row is weakly supported: EIF3J/eIF-3 contributes to post-termination ribosome disassembly/40S recycling and prevents premature 40S-60S joining (noted via the ABCE1 interaction PMID:32296183/35271311), but the review captures this only obliquely (ABCE1 protein-binding KEEP_AS_NON_CORE) and assigns NO QC/recycling process term. So GO:0006515 is not reflected in the review.
- **PN story / NEW pressure:** RQC group projects GO:0006515 protein QC as `new_to_goa`. EIF3J's recycling role is real but is a *recycling/40S-availability* function, not protein quality control / misfolded-chain surveillance; GO:0006515 (protein QC for misfolded/incompletely synthesized proteins) mischaracterizes it and **over-reaches**. A ribosome-recycling/disassembly process term (e.g. GO:0032790 ribosome disassembly) would be more defensible than GO:0006515 if any RQC-row term is projected.
- **Mapping strategy:** Initiation mapping is correct and well-supported. The `Ribosome-associated QC` group → GO:0006515 is too broad/mischaracterizing for EIF3J (a recycling accessory, not a QC factor); recommend not projecting GO:0006515 here.
- **Evidence alignment:** Dossier gives no reference titles. Review anchors PMID:14688252 (j-subunit/40S stable binding, VERIFIED), PMID:17322308/18599441 (eIF-3 MS). Initiation evidence overlaps cleanly; the RQC claim has no dedicated citation in either source.
- **Verdict:** Initiation placement consistent and correct; RQC-group GO:0006515 projection over-reaches (EIF3J is a recycling accessory, not a protein-QC factor). **Recommended edits:** [MAP] drop GO:0006515 projection for EIF3J (or substitute GO:0032790 ribosome disassembly if a recycling term is wanted).