## EIF4E2
- **UniProt:** O60573 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Translation initiation|eIF4F complex` AND `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** initiation type=mapped→GO:0016281 (eIF4F complex); initiation group=mapped→GO:0006413; RQC group=mapped→GO:0006515; RQC type=no_mapping; class/branch context_only (GO:0002181/GO:0006412 too_broad).
- **Consistency:** Mostly consistent on biology but with a sharp, important divergence on one node. Deep research, notes, and review agree: 4EHP is a cap-binding REPRESSOR that cannot bind eIF4G and is NOT a productive eIF4F component; it acts in the 4EHP-GIGYF1/2 RQC/repression module. The review explicitly REMOVEs GO:0016281 (eukaryotic translation initiation factor 4F complex, IBA) and MARK_AS_OVER_ANNOTATED GO:0006413 (translational initiation) as misleading family-level transfers. The PN-node mapping for the "eIF4F complex" type, however, maps to exactly GO:0016281 and the initiation group to GO:0006413 — the two terms the review rejects/downgrades. Direct contradiction at the eIF4F-complex node.
- **PN story / NEW pressure:** PN's RQC framing (GO:0006515, verified real) is fully borne out — review independently asserts negative regulation of translational initiation (GO:0045947, IDA) and rescue of stalled cytosolic ribosome (GO:0072344, IDA) for the RQC module. GO:0006515 is broader than these but defensible as an RQC umbrella; **already captured** (more specifically) by the review.
- **Mapping strategy:** The "eIF4F complex" type→GO:0016281 mapping is wrong for 4EHP and should be revisited at the PN level: 4EHP is a class-II eIF4E paralog that does not assemble into eIF4F. The PN node groups true eIF4F components, but projecting GO:0016281 onto EIF4E2 contradicts curated biology. RQC group→GO:0006515 is acceptable (broad umbrella over the review's GO:0045947/GO:0072344).
- **Evidence alignment:** PN dossier lists no reference titles for EIF4E2; alignment is via projected terms. Review's RQC PMIDs (32726578, 35878012, 22751931, 33053355) cover the same repression/RQC biology the GO:0006515 node encodes. No PMID divergence; the only conflict is term-level (GO:0016281).
- **Verdict:** Biology consistent; one node-level contradiction (PN GO:0016281 vs review REMOVE). RQC story already captured more precisely. **Recommended edits:** [MAP] flag the EIF4E2 "eIF4F complex" type→GO:0016281 projection as inappropriate (4EHP cannot bind eIF4G / is not an eIF4F component — see review REMOVE of GO:0016281); do not propagate GO:0016281 to O60573.