## EIF5A
- **UniProt:** P63241 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Translation elongation|assorted elongation factors` AND `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** elongation type=mapped→GO:0003746 (translation elongation factor activity); elongation group=context_only (GO:0006414); RQC group=mapped→GO:0006515; RQC type=no_mapping; class/branch context_only (GO:0002181/GO:0006412 too_broad).
- **Consistency:** Strong and mutually consistent on the core. Deep research, notes, and review all establish eIF5A as the hypusine-containing elongation/termination factor that binds the 80S ribosome between E and P sites and resolves stalling at polyproline and other difficult motifs. Review ACCEPTs GO:0003746 (elongation factor activity, IBA/IEA/ISS) and GO:0043022 (ribosome binding) as core — matching the PN elongation-type mapping exactly. No contradiction.
- **PN story / NEW pressure:** The PN RQC node (GO:0006515, new_to_goa, verified real) is the only place PN asserts a role beyond the review's elongation framing. eIF5A is indeed described (UniProt; notes) as an RQC cofactor joining the RQC complex to facilitate peptidyl transfer/CAT-tailing, so an RQC-process annotation is defensible — but the review does NOT carry any RQC/GO:0006515 term, treating eIF5A purely as an elongation factor. This is a mild NEW pressure: GO:0006515 is plausibly addable but is a broad umbrella, and eIF5A's RQC role is supportive rather than a dedicated surveillance function. Leans **already captured / mild over-reach**: the elongation-factor activity is the real shared biology; GO:0006515 risks over-stating a QC role for a general elongation factor.
- **Mapping strategy:** Elongation type→GO:0003746 is correct and present in GOA/review. The RQC group→GO:0006515 projection is the borderline call: defensible by UniProt's RQC-cofactor statement, but broad. The group's context_only demotion to GO:0006414 (elongation) is appropriate (the group also houses tRNA synthetases/deacylases). No mapping change required for the elongation node.
- **Evidence alignment:** PN dossier lists no reference titles for EIF5A. Review's core PMIDs (27115996 ribosome binding; 29712776 ATG3/autophagy elongation; 33547280 FABAS disease) all anchor the elongation-factor function the PN elongation node encodes. No divergence.
- **Verdict:** Consistent; elongation core fully captured. GO:0006515 RQC umbrella is defensible but mildly over-reaching for a general elongation factor and is absent from the review. **Recommended edits:** [MAP] treat the EIF5A RQC-group→GO:0006515 projection as low-confidence (eIF5A is an elongation factor with a supportive RQC-cofactor role, not a dedicated surveillance factor); optionally [YAML] consider adding eIF5A's RQC-cofactor role only if curator deems UniProt's CAT-tailing statement annotation-worthy.