## EMC1
- **UniProt:** Q8N766 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE (thorough; ~16 annotations all adjudicated)
- **PN placement:** `ER proteostasis | Protein transport | Transmembrane protein import | EMC complex component`; **PN-node mapping:** type=mapped/ok_for_propagation → GO:0072546 EMC complex (already_in_goa_exact); group→GO:0044743, class→GO:0015031 (both new_to_goa); branch=no_mapping.
- **Consistency:** Strong agreement. Deep research (notes + falcon), review YAML, and PN annotation all describe EMC1 as the large lumenal scaffold subunit of the EMC insertase/chaperone. The review captures EMC complex membership (GO:0072546, multiple IDA/IPI/IBA/IEA), ER membrane localization, membrane insertase activity (GO:0032977 contributes_to), and the specific insertion BPs (GO:0071816, GO:0045050). No contradictions.
- **PN story / NEW pressure:** PN asserts no role beyond what GO already captures. The "Transmembrane protein import" framing is already represented by the specific, experimentally-supported insertion terms (GO:0045050, GO:0071816) plus GO:0032977. No defensible new GO term is needed; the chaperone/holdase mode (PMID:40753078, PMID:37196677) is covered via GO:0051082 in core_functions. Conclusion: already captured.
- **Mapping strategy:** EMC1 does not change the node. type→GO:0072546 is correct and exact. The projected group/class terms (GO:0044743 protein transmembrane import into intracellular organelle; GO:0015031 protein transport) are BROADER than the review's specific insertion terms — same broader-ancestor pattern rejected for TOMM20/HSPA8/RAB7A. They are defensible as ancestor propagation but add no specificity over existing GOA.
- **Evidence alignment:** Excellent overlap. Both rest on PMID:22119785 (EMC discovery), PMID:29242231 (insertase), PMID:32439656 (structure). Review adds EMC1-specific depth (CAVIPMR genetics PMID:38784058; client engagement PMID:37196677, PMID:40753078). PN cites no row-1 reference titles, so no divergence to flag.
- **Verdict:** Consistent; PN adds no NEW pressure; projected group/class terms broader than review (no mapping change warranted).