## EMC2
- **UniProt:** Q15006 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE (very thorough; ~36 annotations, many high-throughput protein-binding all adjudicated)
- **PN placement:** `ER proteostasis | Protein transport | Transmembrane protein import | EMC complex component`; **PN-node mapping:** type=mapped/ok_for_propagation → GO:0072546 EMC complex (already_in_goa_exact); group→GO:0044743, class→GO:0015031 (new_to_goa); branch=no_mapping.
- **Consistency:** Strong agreement. Deep research, review YAML, and PN annotation concur: EMC2 (TTC35) is the cytosolic TPR scaffold subunit of the EMC. Review captures GO:0072546 (IBA/IPI/IDA), ER membrane + extrinsic-component-of-ER-membrane (GO:0042406), GO:0032977 (contributes_to), and insertion BPs. WNK1 assembly factor (PMID:33964204) well documented. No contradictions.
- **PN story / NEW pressure:** PN asserts nothing beyond GO coverage. EMC2's distinctive biology (WNK1-shielded assembly, ubiquitin-proteasome turnover of orphan EMC2) is recorded in description/core_functions but is correctly not forced into a new GO term. The "transmembrane protein import" role is captured by the specific insertion terms. Conclusion: already captured.
- **Mapping strategy:** EMC2 does not change the node. type→GO:0072546 exact and correct. Projected group/class terms (GO:0044743, GO:0015031) are broader than the review's specific insertion terms (GO:0045050, GO:0071816, GO:0032977) — the broader-ancestor pattern rejected for TOMM20/HSPA8/RAB7A. No mapping change warranted.
- **Evidence alignment:** Excellent overlap on core EMC papers (PMID:22119785, PMID:29242231, PMID:32439656, PMID:30415835). Review adds EMC2-specific PMID:33964204 (WNK1/scaffold) and the long roster of HuRI/BioPlex/OpenCell interactomes (all LOW relevance, correctly KEEP_AS_NON_CORE). PN cites no row-1 titles; no divergence.
- **Verdict:** Consistent; PN adds no NEW pressure; projected group/class terms broader than review (no mapping change warranted).