## EMC3
- **UniProt:** Q9P0I2 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE (thorough; all annotations adjudicated)
- **PN placement:** `ER proteostasis | Protein transport | Transmembrane protein import | EMC complex component`; **PN-node mapping:** type=mapped/ok_for_propagation → GO:0072546 EMC complex (already_in_goa_exact); group→GO:0044743, class→GO:0015031 (new_to_goa); branch=no_mapping.
- **Consistency:** Strong agreement, and notably EMC3 is the catalytic insertase subunit (Oxa1/YidC/Get1 superfamily) forming the EMC3/EMC6 vestibule. Deep research, review, and PN annotation are aligned. Review correctly elevates GO:0032977 membrane insertase activity to core (contributes_to, but distinguished from accessory subunits by vestibule mutagenesis R31/R180, Met-rich loop). GO:0072546, ER membrane, and insertion BPs all captured. No contradictions.
- **PN story / NEW pressure:** PN ("transmembrane protein import" / "EMC complex component") asserts nothing beyond GO coverage. EMC3's catalytic/selectivity-filter role (PMID:37199759) is captured by GO:0032977 + insertion BPs. No new GO term warranted. Conclusion: already captured.
- **Mapping strategy:** EMC3 does not change the node. type→GO:0072546 is correct/exact for complex membership; importantly the EMC complex CC term (membership) is correctly distinguished from EMC3's catalytic insertase MF — the PN node maps only membership, which is right. Projected group/class terms (GO:0044743, GO:0015031) are broader than the review's specific terms — broader-ancestor pattern (cf. TOMM20/HSPA8/RAB7A). No mapping change warranted.
- **Evidence alignment:** Excellent overlap (PMID:22119785, PMID:29242231, PMID:32439656, PMID:30415835). Review adds EMC3-specific mechanistic depth: selectivity filter PMID:37199759, topology rectification PMID:37957425, in vivo rhodopsin/photoreceptor requirement PMID:31263175. PN cites no row-1 titles; no divergence.
- **Verdict:** Consistent (EMC3 = catalytic core, correctly handled); PN adds no NEW pressure; projected group/class terms broader than review (no mapping change warranted).