## EMC4
- **UniProt:** Q5J8M3 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE (thorough; all annotations adjudicated)
- **PN placement:** `ER proteostasis | Protein transport | Transmembrane protein import | EMC complex component`; **PN-node mapping:** type=mapped/ok_for_propagation → GO:0072546 EMC complex (already_in_goa_exact); group→GO:0044743, class→GO:0015031 (new_to_goa); branch=no_mapping.
- **Consistency:** Strong agreement. EMC4 (TMEM85) is an accessory/structural membrane subunit (three-TMD vestibule sidewall, not catalytic). Deep research, review, and PN annotation concur. Review captures GO:0072546, ER membrane, GO:0032977 (contributes_to, correctly NOT elevated to catalytic), and insertion BPs. No contradictions.
- **PN story / NEW pressure:** PN asserts nothing beyond GO coverage. EMC4 has additional distinctive non-core biology in the review (flavivirus host factor PMID:31273220/PMID:31067454; SV40 late-endosome-ER tethering via Rab7/syntaxin18 PMID:32111841; putative EMC3/EMC4 lipid-scramblase PMID:38621120) — all correctly kept as context/non-core, none rising to a defensible NEW GO term (scramblase is computational/not demonstrated for human EMC4 in vivo). Conclusion: already captured.
- **Mapping strategy:** EMC4 does not change the node. type→GO:0072546 exact/correct. Projected group/class terms (GO:0044743, GO:0015031) are broader than the review's specific insertion terms — broader-ancestor pattern (cf. TOMM20/HSPA8/RAB7A). The tethering/scramblase roles are EMC4-specific but are not part of the PN "transmembrane protein import" node and should not alter it. No mapping change warranted.
- **Evidence alignment:** Excellent overlap on core EMC papers (PMID:22119785, PMID:29242231, PMID:32439656, PMID:30415835, PMID:37199759, PMID:37196677, PMID:38517390). Review adds EMC4-specific functional-genetics references absent from PN. PN cites no row-1 titles; no divergence.
- **Verdict:** Consistent; PN adds no NEW pressure; projected group/class terms broader than review (no mapping change warranted).