## ERLIN1
- **UniProt:** O75477 (ERLN1_HUMAN, SPFH1) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE (all annotations actioned; no PENDING).
- **PN placement:** `ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates` and `Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7` ; **PN-node mapping:** [group ERAD] mapped/exact GO:0036503; [type ER-handling] mapped/ok_for_propagation GO:0036503; [group idiosyncratic RING complex] mapped/ok_for_propagation GO:0000151 ubiquitin ligase complex; subtype/type/branch no_mapping; UPS class context_only/too_broad GO:0061630.
- **Consistency:** Strong. Deep research (Veronese 2024 scaffold/TMUB1-RNF170; Cogan 2024 SPG62; Manganelli 2021 rafts/MAM) ↔ review YAML (ERAD of IP3R, cholesterol binding, SREBP restriction, ER-membrane raft, E3-ligase binding) ↔ PN annotation (BAND 7 noncatalytic ERLIN/RNF170 complex; ERAD) all agree. No contradictions. ERLIN dossier identical to ERLIN2 (shared complex).
- **PN story / NEW pressure:** PN asserts ERAD + non-catalytic E3-complex membership. Both already captured: GO:0036503 (IDA PMID:19240031, multiple ECs) and GO:0031625 ubiquitin protein ligase binding (IEA) are present. The 2024 scaffold/cholesterol-esterification/secretory-pathway role (Veronese, PMID:38782601) is NOT in GOA but is cited in references. No new term is forced; the most defensible additions would be MF GO:0160072 "ubiquitin ligase complex scaffold activity" (verified real) capturing the non-catalytic adaptor role. Verdict: largely already captured; scaffold-activity term is an optional ADD.
- **Mapping strategy:** ERAD mapping (GO:0036503) is correct and already-in-GOA-exact. The GO:0000151 projection over-reaches slightly: the ERLIN1/2 complex (CPX-7121) is a non-catalytic BAND 7 scaffold, whereas GO:0000151 is a *catalytic* ubiquitin-ligase complex. GO:0000835 "ER ubiquitin ligase complex" (verified real) is the more accurate, still-broader-than-GOA target if a complex CC is projected.
- **Evidence alignment:** PN cites only opaque workbook IDs (1610068, 41481136 — not PMIDs of the key ERLIN papers). Review/notes anchor to PMID:19240031, 24217618, 21343306, 38782601 + ComplexPortal CPX-7121. Divergence is presentational, not substantive.
- **Verdict:** Consistent and high-quality; PN story already captured by GOA/review. GO:0000151 projection mildly over-reaches (non-catalytic scaffold); prefer GO:0000835 / GO:0160072.

**Recommended edits:** [MAP] Replace/qualify the GO:0000151 group projection with GO:0000835 "ER ubiquitin ligase complex" (CC) for the ERLIN/RNF170 assembly, noting ERLINs are non-catalytic BAND 7 subunits. [YAML, optional] Consider adding MF GO:0160072 "ubiquitin ligase complex scaffold activity" to core_functions for the adaptor role.