## ERP29
- **UniProt:** P30040 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE (exhaustive; ~32 annotations, notes present, no provider deep-research file)
- **PN placement:** `ER proteostasis|Folding enzyme|Protein disulfide isomerases` ; **PN-node mapping:** group (Protein disulfide isomerases)→GO:0003756 protein disulfide isomerase activity (mapped/ok_for_propagation, goa_status=new_to_goa); class (Folding enzyme)→no_mapping; branch→no_mapping.
- **Consistency:** Review, notes, and UniProt agree that ERP29 is a non-catalytic, redox-inactive PDI-family escort/chaperone — it has a thioredoxin-like fold but LACKS the CXXC (CGHC) active-site motif and is NOT a disulfide isomerase. The PN-node mapping CONTRADICTS this: the "Protein disulfide isomerases" group projects GO:0003756 positively onto ERP29, but ERP29's only GOA annotation to GO:0003756 is `NOT|enables` (IKR, PMID:9738895) and the review ACCEPTs that negation. So the PN group rationale ("catalytically active family members") is correct only for the catalytic PDIs — ERP29 is the family exception, mis-swept into the group projection.
- **PN story / NEW pressure:** GO:0003756 (VERIFIED real via OLS) is a catalytic isomerase activity ERP29 demonstrably does not have. This is not a defensible NEW term for ERP29 — it directly opposes the negated experimental annotation and the no-CXXC biology. The review's true core MF is GO:0051087 protein-folding chaperone binding (ACCEPT), already captured. Conclude: OVER-REACHES (worse — actively contradicted), do NOT add.
- **Mapping strategy:** This gene SHOULD change the group projection. The catalytic-PDI mapping (GO:0003756) is the right target for active members (PDIA1, etc.) but must NOT propagate to the non-catalytic ERP29; the group node needs a per-member exclusion or ERP29 should map to a chaperone-binding/escort term (GO:0051087) instead.
- **Evidence alignment:** PN node carries no reference titles. Review well-anchored: PMID:9738895 (lacks CXXC; founding characterization, VERIFIED) and PMID:12475965 (ER chaperone multiprotein complex, VERIFIED). No shared evidence supports a disulfide-isomerase-activity claim; the cited PMID:9738895 in fact establishes the opposite.
- **Verdict:** OVER-REACHES / CONTRADICTED — reject projected GO:0003756 for ERP29; the gene is a non-catalytic PDI member whose function is already captured by GO:0051087. **Recommended edits:** [MAP] do not propagate GO:0003756 to ERP29 (it carries a curated NOT for this term); exclude non-catalytic PDI-family members from the group's isomerase projection or re-map ERP29 to GO:0051087 protein-folding chaperone binding.