## FBXL13
- **UniProt:** Q8NEE6 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; F-box+LRR subtype/type `no_mapping`; class `context_only / too_broad / GO:0061630`; branch `no_mapping`.
- **Consistency:** Strong. Falcon deep research, review YAML, and PN node mapping agree FBXL13 is an SCF substrate receptor that degrades CEP192 at the centrosome (PMID:29348145), plus a moonlighting N-DRC/DRC6 axonemal structural role (PMID:37258679). No contradictions. The dual identity (centrosomal SCF vs ciliary structural subunit) is handled by KEEP_AS_NON_CORE on all N-DRC terms — coherent with PN's UPS-only framing.
- **PN story / NEW pressure:** PN asserts only the generic adaptor MF (GO:1990756, verified real). GOA carries NO MF term for FBXL13 at all (only BP/CC). The review adds GO:1990756 in core_functions (no existing MF to MODIFY). Not over-reaching. The ciliary structural role (GO:0005198 structural molecule activity) is a genuine second MF the PN UPS lens does not capture, but it is correctly off-mapped as non-core. Conclusion: adaptor MF appropriately ADDED; no defensible UPS NEW-term gap.
- **Mapping strategy:** Gene does not change the node. F-box catalysis correctly excluded from sub-nodes (RBX1 RING). One caveat: CEP192 is a validated substrate, so FBXL13 is NOT an orphan adaptor — adaptor MF is experimentally grounded, not inferred-only. PN-projected GO:1990756 matches review core_functions exactly (not broader/narrower).
- **Evidence alignment:** PN reference is only "15340381/rev" (family placeholder, PMID:15340381). The review does not cite it; its PMIDs (29348145, 33234069, 37258679) are gene-specific and richer. Benign divergence.
- **Verdict:** CONSISTENT / ACCEPT mapping. No edits required; adaptor-MF pattern correctly applied; substrate (CEP192) validated.