## FBXL14
- **UniProt:** Q8N1E6 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; F-box+LRR subtype/type `no_mapping`; class `context_only / too_broad / GO:0061630`; branch `no_mapping`.
- **Consistency:** Strong. Falcon, review YAML, and PN mapping agree FBXL14 is the SCF(FBXL14) substrate receptor degrading SNAI1/SNAIL1 (PMID:19955572, IDA), with falcon adding HES1 (WRPW motif) and Thr58-phospho-c-MYC substrate axes. No contradictions.
- **PN story / NEW pressure:** PN asserts the generic adaptor MF (GO:1990756, verified real). GOA carries catalytic `GO:0004842 ubiquitin-protein transferase activity` (IDA) — the classic F-box mis-attribution of RBX1-RING catalysis to the receptor. The review correctly MODIFY's GO:0004842 → GO:1990756 AND adds GO:1990756 as a NEW IDA annotation. Bare `protein binding` (SNAI1, SKP1; 6 IPI rows) kept non-core. This is the canonical correct call. No unmet UPS NEW-term gap (SNAI1/HES1 degradation captured by GO:0031146/GO:0006511).
- **Mapping strategy:** Gene does not change the node. Status/scope right; catalysis excluded from sub-nodes. SNAI1 (and HES1) are validated substrates → adaptor MF experimentally grounded, not orphan/inferred-only. PN-projected GO:1990756 matches review core_functions MF exactly.
- **Evidence alignment:** PN reference only "15340381/rev" (placeholder); review does not cite it. Review PMIDs (19955572 primary; 33234069 family; plus high-throughput SKP1 interactome PMIDs) are gene-specific. Benign divergence.
- **Verdict:** CONSISTENT / ACCEPT mapping. No edits required; MODIFY(GO:0004842→GO:1990756) + NEW pattern correctly applied; substrate validated.