## FBXL15
- **UniProt:** Q9H469 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; F-box+LRR subtype/type `no_mapping`; class `context_only / too_broad / GO:0061630`; branch `no_mapping`.
- **Consistency:** Strong. Falcon, review YAML, and PN mapping agree FBXL15 (FBXO37) is the SCF(FBXL15) substrate receptor that degrades the HECT ligase SMURF1 (also SMURF2/WWP2), positively regulating BMP signaling (PMID:21572392, IDA-rich). Falcon refines the SMURF1 degron (K357/K355) and BMP readout (ID1/SMAD6) — consistent. One internal caveat handled well: the IMP G2/M annotation (GO:0000086) is left UNDECIDED because the abstract foregrounds BMP, not cell cycle — correct per "don't overrule curators" guidance.
- **PN story / NEW pressure:** PN asserts generic adaptor MF (GO:1990756, verified real). GOA carries only `protein binding` (IPI) as MF. The review adds GO:1990756 as a NEW IDA annotation; bare protein binding kept non-core. Correct call. Downstream BP roles (BMP regulation, bone mineralization, D/V patterning) are already annotated and kept non-core — no UPS NEW-term gap.
- **Mapping strategy:** Gene does not change the node. Catalysis correctly excluded from sub-nodes (RBX1 RING). SMURF1 is a validated substrate (LRR recognizes HECT N-lobe) → adaptor MF grounded, not orphan. PN-projected GO:1990756 matches review core_functions MF exactly. Note: substrate is itself a HECT E3, so this is an E3-degrades-E3 node — does not change mapping.
- **Evidence alignment:** PN reference only "15340381/rev" (placeholder); review does not cite it. Review centers on PMID:21572392 (primary, full text) + falcon. Benign divergence.
- **Verdict:** CONSISTENT / ACCEPT mapping. No edits required; NEW(GO:1990756) pattern correctly applied; substrate validated; G2/M UNDECIDED appropriately conservative.