## FBXL17
- **UniProt:** Q9UF56 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; F-box+LRR subtype/type `no_mapping`; class `context_only / too_broad / GO:0061630`; branch `no_mapping`.
- **Consistency:** Strong. Falcon, review YAML, and PN mapping agree FBXL17 is the SCF(FBXL17) substrate receptor. Multiple validated substrates: BACH1 (PMID:24035498), SUFU (PMID:27234298), and the hallmark **dimerization quality control (DQC)** of aberrant BTB dimers (PMID:30190310, IDA). Falcon adds the 2024 remodeling/monomerization mechanism (vs FBXO22 reading intact dimers), PRMT1 acetyl-degron, and SPAST-M1 — well-grounded; non-canonical recognition consistently captured. No contradictions.
- **PN story / NEW pressure:** PN asserts generic adaptor MF (GO:1990756, verified real); GOA carries only `protein binding` (IPI) as MF. Review adds GO:1990756 as NEW IDA; bare protein binding (SKP1, BACH1, SUFU, KLHL12, SPAST) kept non-core. Correct. The distinctive DQC biology IS a genuine gap: review maps it to GO:0006515 (protein QC for misfolded/incomplete proteins, verified real) but flags that this does not capture quaternary-structure/dimer-interface surveillance, and proposes a NEW BP "dimerization quality control of BTB-domain protein assemblies" (candidate, UNVERIFIED — not yet a real GO ID; defensible, well-justified, parent GO:0006515). Conclusion: adaptor MF ADDED correctly; DQC NEW term is a strong candidate awaiting GO submission.
- **Mapping strategy:** Gene does not change the group node, but is the strongest **non-canonical F-box** in the set — it recognizes a quaternary degron via dimerization-quality-control, not a linear/single-protomer degron. Adaptor MF (GO:1990756) still applies (it does form a productive SCF and ubiquitinates substrates), so the group mapping holds. Substrates validated → not orphan. Catalysis correctly excluded from sub-nodes.
- **Evidence alignment:** PN reference only "15340381/rev" (placeholder); review does not cite it. Review uses three primary PMIDs (24035498, 27234298, 30190310, all verified) + falcon. Strong, gene-specific evidence; benign divergence from placeholder.
- **Verdict:** CONSISTENT / ACCEPT mapping. No YAML edits required. **Flag: non-canonical (DQC) recognition** — noted in brief; group GO:1990756 still valid. DQC NEW BP term is candidate/unverified (worth proposing to GO).