## FBXL3
- **UniProt:** Q9UKT7 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; F-box/LRR subtype+type `no_mapping`; class `context_only / too_broad / GO:0061630`.
- **Consistency:** Strong. Deep research (falcon), review YAML, PN annotation, and node mapping all describe FBXL3 as the SCF(FBXL3) substrate receptor that degrades CRY1/CRY2 to set circadian period. No contradictions. Falcon-only leads (K48 chain elongation, substrate-gated assembly, KL001 pocket) are flagged UNVERIFIED but corroborated by the experimental cache (PMID:17463251 IMP/IDA; PMID:23503662 structure).
- **PN story / NEW pressure:** PN asserts only the generic adaptor MF (GO:1990756). This is NOT already an MF in the GOA, which carries only catalytic `GO:0004842` (IDA/IEA/NAS) + `protein binding`. The review correctly MODIFY's the two catalytic transferase annotations to GO:1990756 (verified real, current). No new BP pressure; circadian/SCF-catabolism BPs already captured. Conclusion: adaptor MF added by MODIFY = correct, not over-reaching.
- **Mapping strategy:** Gene does not change the node. Status/scope are right: the F-box adaptor MF lives at the group node, catalysis correctly excluded from the F-box/LRR sub-nodes (RBX1 RING does catalysis). PN-projected GO:1990756 matches the review's core_functions MF exactly (neither broader nor narrower). Canonical, well-validated SCF receptor (CRY substrate validated) — no orphan flag.
- **Evidence alignment:** PN reference is only "15340381/rev" (PMID:15340381, an FBXL/Cul1 review). The review does NOT cite PMID:15340381; its key PMIDs (17463251, 23503662, 10531035, 33234069) are richer/gene-specific. Divergence is benign — PN uses a family-level placeholder; review uses primary literature.
- **Verdict:** CONSISTENT / ACCEPT mapping. No edits required; the MODIFY→GO:1990756 pattern is correctly applied. Optional [REF]: PN-row reference PMID:15340381 not reflected in review (placeholder only).