## FBXL5
- **UniProt:** Q9UKA1 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; class `context_only / too_broad / GO:0061630`.
- **Consistency:** Strong. Deep research, review YAML, PN annotation, and node mapping agree: FBXL5 is the iron/oxygen-sensing SCF substrate receptor for IRP2/IREB2. Rich experimental backbone (PMID:19762596 IMP/IDA, 19762597 IDA/IEP, 17532294 DCTN1, 24157836 SNAI1). No contradictions.
- **PN story / NEW pressure:** PN asserts only the generic adaptor MF. The review goes well beyond: it keeps the experimentally validated `GO:0005506 iron ion binding` (IDA) as a co-core MF — a real function the PN mapping does NOT capture — and MODIFY's the catalytic `GO:0004842` (NAS) to GO:1990756. The review also PROPOSES a new term "iron- and oxygen-sensing ubiquitin-ligase substrate adaptor activity" (child of GO:1990756). OLS search returns no existing GO equivalent, so this is a legitimate candidate-new-term, not a duplicate; correctly justified as more precise than GO:1990756. Conclusion: adaptor MF captured; the iron-sensing MF + proposed child are an ADD beyond the PN story (defensible).
- **Mapping strategy:** Gene does not change the node; group GO:1990756 is appropriate and matches review core_functions. PN scope correct. The metal-sensing layer is gene-specific and rightly stays out of the shared node mapping. Canonical, validated-substrate receptor — no orphan flag.
- **Evidence alignment:** PN cites only "15340381/rev" (PMID:15340381). The review does not cite it; it uses gene-specific primaries plus falcon. Benign placeholder divergence.
- **Verdict:** CONSISTENT / ACCEPT mapping. No edits needed. Note: proposed_new_term (iron/oxygen-sensing adaptor) is verified as not pre-existing in GO — keep as candidate (unverified existence elsewhere, but no GO clash).