## FBXL8
- **UniProt:** Q96CD0 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** group-level `mapped / ok_for_propagation_to_go / GO:1990756`; class `context_only / too_broad / GO:0061630`.
- **Consistency:** Mostly consistent, with one structural gap. Review, PN annotation, and node mapping agree FBXL8 is an SCF substrate receptor. **Non-canonical F-box: UniProt notes FBXL8 does NOT contain canonical leucine-rich repeats despite the "LRR" name** — yet the PN places it under the `...|F-box|LRR` subtype. The review captures this caveat in its description; the PN subtype label is therefore mildly inaccurate for this member (subtype is `no_mapping`, so no propagation harm). Falcon substrates (p53, phospho-Thr283 CCND3, Snail1, unphospho c-MYC) are UNVERIFIED leads, correctly not added as GO terms.
- **PN story / NEW pressure:** PN asserts the generic adaptor MF. FBXL8 GOA has NO MF beyond `protein binding` (SKP1) and no SCF-process IDA. The review's core_functions assigns `GO:1990756`, but — unlike FBXL7/FBXL12 — **it is NOT added as an `action: NEW` entry in existing_annotations.** This is the one batch-pattern deviation: the adaptor MF that PN projects as new_to_goa is endorsed in core_functions but never materialized as a reviewable annotation. Conclusion: ADD GO:1990756 as NEW to existing_annotations for parity.
- **Mapping strategy:** Gene does not change the group GO:1990756 (defensible on F-box + SKP1 grounds). **FLAGS: (1) non-canonical F-box (no true LRRs) — PN `|LRR` subtype label is a misnomer here; (2) no PMID-validated substrate in existing_annotations — adaptor MF is inferred-only.** Scope/status otherwise correct.
- **Evidence alignment:** PN cites only "15340381/rev"; review uses SKP1 interactome PMIDs + PMID:33234069 + falcon leads. No PMID overlap with placeholder.
- **Verdict:** MAPPING CONSISTENT but YAML gap. **Recommended edits:** [YAML] add `GO:1990756` as `action: NEW` in FBXL8 existing_annotations (mirror FBXL7/FBXL12) so the PN-projected adaptor MF is materialized; [MAP] consider noting the non-canonical (no-LRR) status on the F-box|LRR subtype for FBXL8.