## FBXO17

- **UniProt:** Q96EF6 · **batch:** proteostasis-batch-2026-06-13 (Falcon DR) · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA` (lectin subfamily, aux domain IPR007397) ; **PN-node mapping:** subtype/type `no_mapping`; group `Cul1 substrate receptor`=`mapped` / `ok_for_propagation_to_go` → GO:1990756 (new_to_goa); class `context_only`/`too_broad` (GO:0061630).
- **Consistency:** Largely consistent, with a deliberate MF divergence. PN projects the generic adaptor MF (GO:1990756); the review instead makes GO:0030246 carbohydrate binding the core MF (NEW, IDA PMID:18203720) — correct for an FBA/lectin F-box, and a refinement of, not a contradiction with, the PN family story. DR (GSK3beta substrate, IRF3/PP2A non-canonical mode) ↔ YAML agree.
- **PN story / NEW pressure:** SPECIAL CASE re-examined. ERAD IBA (GO:0036503, verified real) is correctly MARK_AS_OVER_ANNOTATED: PMID:18203720 shows FBXO17 does NOT bind high-mannose glycans (only FBXO2/FBXO6 do GERAD), so the family ERAD propagation over-reaches — review call stands. Review ADDs GO:0030246 carbohydrate binding (verified real) — defensible, evidence-backed lectin MF absent from GOA. GO:0006516 glycoprotein catabolic process (verified real) ACCEPTed. Validated PROTEIN substrate exists (GSK3beta, Suber 2017) so not substrate-less.
- **Mapping strategy:** Gene refines the node's MF: PN's GO:1990756 is generic; for the FBA leaf the more informative MF is the lectin GO:0030246 (review) and the family adaptor role is still captured by the contributes_to GO:0061630. PN-projected GO:1990756 is broader than the review's chosen core MF — flag as the one place where PN altitude is less specific than the gene-level call.
- **Evidence alignment:** PN cites only 15340381. Review anchors on PMID:18203720 (HIGH, full text, the lectin/SCF characterization) plus many interactome PMIDs (all non-core protein binding) and Falcon GSK3beta/IRF3 leads (VERIFIED notes). Strong divergence in depth, no conflict.
- **Verdict:** Consistent; ERAD over-annotation call confirmed (no high-mannose binding). PN's generic GO:1990756 under-specifies the FBA lectin MF — review's GO:0030246 is the better gene-level MF.
- **Recommended edits:** none to FBXO17-ai-review.yaml (ERAD MARK_AS_OVER_ANNOTATED and NEW carbohydrate-binding are sound). [MAP] for the FBA subfamily, prefer GO:0030246 (lectin) as the informative MF at gene level rather than propagating the generic GO:1990756; do not propagate ERAD (GO:0036503) from the FBA node to FBXO17.