## FBXO2

- **UniProt:** Q9UK22 (FBXO2/FBG1/Fbs1) · **batch:** proteostasis-batch-2026-06-13 (Falcon DR) · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA` ; **PN-node mapping:** group `Cul1 substrate receptor`=`mapped`/ok_for_propagation→GO:1990756; F-box/FBA subtype+type=`no_mapping`; class=`context_only`/too_broad→GO:0061630.
- **Consistency:** Consistent on substance; one nuance. Falcon DR, review YAML, and the PN FBA F-box receptor placement converge on FBXO2 as a lectin-type SCF substrate receptor for glycoprotein-ERAD. SPECIAL CASE confirmed: FBA = real carbohydrate-binding MF (GO:0030246, verified real), recognizing the innermost Man3GlcNAc2 N-glycan core on misfolded glycoproteins.
- **PN story / NEW pressure:** PN projects the generic GO:1990756 adaptor term (new_to_goa). The review's chosen **core MF is the more informative, substrate-class-specific GO:0030246 carbohydrate binding (ACCEPT, already in GOA via IEA/keyword Lectin)** — a genuine lectin activity beyond bare adaptor binding. Review also correctly demotes catalytic TAS GO:0004842/GO:0061630 to non-core/contributes_to. Conclude: PN adaptor term is captured at family level but the gene's distinctive MF (carbohydrate binding) is already in GOA and is the better core — no new term needed; FBXO2 lectin function over-rides the generic adaptor projection.
- **Mapping strategy:** Gene refines, does not change, the node. The GO:1990756 group projection is the lowest-common-denominator F-box MF; for the FBA lectin subfamily the more specific GO:0030246 is preferable and already present, so the projection is not wrong but is broader than the gene's best MF. Consider noting FBA-lectin subfamilies carry carbohydrate binding as the distinguishing MF.
- **Evidence alignment:** PN reference only "15340381 / rev"; review draws on PMID:10531035 (family), PMID:18203720-equivalent FBA-lectin work (cited heavily for FBXO6), PMID:34515398 (xenophagy/glycan, HIGH/VERIFIED), PMID:34445249, plus Falcon DR (Yoshida/Suzuki reviews, lysophagy). Strong gene-specific evidence; PN family review is a subset.
- **Verdict:** Consistent; core MF correctly GO:0030246 (lectin, in GOA) rather than the generic PN adaptor term. No over-reach; secondary xenophagy/lysophagy/synaptic roles kept non-core.
- **Recommended edits:** none to FBXO2-ai-review.yaml. [MAP] Optionally annotate FBA-lectin F-box subfamily nodes so carbohydrate binding (GO:0030246) is recognized as their distinguishing MF alongside the generic GO:1990756.