## FBXO22
- **UniProt:** Q8NEZ5 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (well-developed; ~30 annotations reviewed)
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other` ; **PN-node mapping:** group=mapped, scope=ok_for_propagation_to_go, GO:1990756 (ubiquitin-like ligase-substrate adaptor activity); subtype/type/branch=no_mapping; class=context_only (GO:0061630, too_broad).
- **Consistency:** Strong. Deep research (Falcon), UniProt, GOA, and review YAML all agree FBXO22 is the SCF/CRL1 substrate receptor (substrates KDM4A/B, methylated TP53, BACH1, nuclear PTEN K221, PD-L1, BAG3, MTOR, NSP5). Review MODIFY of GO:0004842 (TAS transferase) → GO:1990756 exactly matches the PN group target. No contradictions.
- **PN story / NEW pressure:** PN asserts only the generic adaptor role, already captured by the review (core_function MF = GO:1990756, verified real, def. "Usually mediated by F-box…proteins"). The rich substrate biology vastly exceeds GOA but the review correctly declines substrate-specific NEW terms (proposed_new_terms empty). Conclusion: PN adaptor claim ALREADY CAPTURED; substrate detail belongs in core_functions, not new GO.
- **Mapping strategy:** Correct. This gene does not change the node; it is the canonical exemplar of the MODIFY-catalytic-MF→GO:1990756 pattern. GO:1990756 is neither broader nor narrower than the review's chosen core MF — they are identical. Class-level GO:0061630 correctly held as context_only/too_broad.
- **Evidence alignment:** PN cites only "15340381 / rev" (PMID:15340381, an F-box family review; not in this review's reference list). Review is anchored on substrate-specific primary papers (PMID:37979583 MTOR, PMID:39223933 NSP5) plus founding F-box papers (PMID:10531035/10531037) and PMID:34445249. Divergence: PN's single review reference is thinner than and disjoint from the review's evidence base, but both support the same adaptor framing.
- **Verdict:** CONSISTENT — no changes needed. Exemplary application of the F-box adaptor pattern.