## FBXO27
- **UniProt:** Q8NI29 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (well-developed; SPECIAL CASE — lectin F-box)
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA` (aux domain IPR007397) ; **PN-node mapping:** group=mapped GO:1990756; subtype/type/branch=no_mapping; class=context_only (GO:0061630).
- **Consistency:** Good, with a deliberate divergence. As an FBA/FBG lectin F-box, the review (correctly) does NOT make GO:1990756 the core MF; instead core MF = GO:0030246 carbohydrate binding (+ proposed GO:0005537 D-mannose binding), with GO:0006516 glycoprotein catabolic process and lysophagy as core BP. Deep research (Yoshida/Fbs3 lysophagy of LAMP2/LAMP1), UniProt (2008 lectin/SCF data), and GOA agree. The contributes_to GO:0061630 IBA is reasonably kept non-core. No internal contradictions.
- **PN story / NEW pressure:** PN's generic GO:1990756 adaptor target does NOT match this gene's informative MF (glycan binding) — a known special case the prompt flagged. Review adds the lysophagy/damaged-lysosome-glycoprotein role (LAMP2/LAMP1, p62/LC3, N-myristoylation) absent from GOA. KEY ISSUE: review proposes "lysophagy" as a NEW term, but **GO:0062093 lysophagy already exists** (verified; child of GO:0016236 macroautophagy, def. "selective autophagy…damaged lysosome…by macroautophagy"). So this is ALREADY CAPTURED in GO, not new. Also GO:0097466 "ubiquitin-dependent glycoprotein ERAD pathway" exists as a more specific option than the ERAD IBA.
- **Mapping strategy:** Node mapping is fine for the family, but PN's GO:1990756 over-reaches/under-describes FBXO27 specifically — glycan binding is the real MF. Reviewer already handled this at the gene level (MODIFY protein-binding → carbohydrate binding). No node change needed; flag FBXO27 as the lectin exception to the GO:1990756 default.
- **Evidence alignment:** PN cites only "15340381 / rev". Review anchored on PMID:18203720 (FBA lectin family, full text) + Falcon (Yoshida PNAS lysophagy) + PMID:34445249. PN reference disjoint from review's; review evidence is far richer and substrate-validated.
- **Verdict:** CONSISTENT (with lectin caveat); ONE FIX — replace the proposed-new "lysophagy" with existing GO:0062093.
- **Recommended edits:** [YAML] In FBXO27-ai-review.yaml, replace the `proposed_new_terms` "lysophagy" entry with a reference to existing **GO:0062093 lysophagy** (verified real), and set core_function #3 `directly_involved_in` to GO:0062093 (more specific than GO:0016236 macroautophagy). [YAML] Optionally MODIFY the ERAD IBA (GO:0036503) toward **GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway** if retained.