## FBXO30
- **UniProt:** Q8TB52 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (well-developed; relatively poorly characterized gene)
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF` (aux domain IPR001293) ; **PN-node mapping:** group=mapped GO:1990756; subtype/type/branch=no_mapping; class=context_only (GO:0061630).
- **Consistency:** Strong. Deep research (Falcon → RARG, HIF-1A human; Eg5/KIF11, SLBP mouse), UniProt and GOA concordant on SCF/CRL1 substrate-receptor role. Review MODIFY of GO:0061630 (InterPro IEA ubiquitin protein ligase activity) → GO:1990756 matches the PN group target precisely. TRAF-type ZnF GO:0008270 zinc binding kept non-core (structural). No contradictions.
- **PN story / NEW pressure:** PN asserts only the generic adaptor MF, already captured (core_function MF = GO:1990756, verified). Falcon substrates (RARG/HIF-1A/Eg5/SLBP) are single-study leads; review correctly does NOT promote them to substrate-specific GO terms (proposed_new_terms empty). Conclusion: PN adaptor claim ALREADY CAPTURED; no defensible NEW term.
- **Mapping strategy:** Correct; gene does not change the node. GO:1990756 equals the review's core MF. The catalytic-ligase IEA (GO:0061630) is exactly the over-propagation the F-box pattern predicts, correctly MODIFIED here. Note GO:0061630 also appears as the class-level context_only target — at the gene level it is properly demoted, not propagated.
- **Evidence alignment:** PN cites only "15340381 / rev" (not in review refs). Review anchored on Falcon-sourced primary studies (Cheng 2019, Yuan 2023, Liu 2016, Jin 2019 — author-year, UNVERIFIED), the BioPlex interactome PMIDs (MYO6), and PMID:34445249. Divergence: PN reference disjoint; review's substrate evidence is lead-grade (Falcon DOIs not re-verified) but consistent with adaptor framing.
- **Verdict:** CONSISTENT — no changes needed.