## FBXO33
- **UniProt:** Q7Z6M2 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (well-developed)
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` (aux domain IPR032675) ; **PN-node mapping:** group=mapped GO:1990756; subtype/type/branch=no_mapping; class=context_only (GO:0061630).
- **Consistency:** Strong. Deep research (Falcon → YBX1, ATXN3/polyQ, MYC, p53 substrates), UniProt and GOA agree FBXO33 is the SCF(FBXO33) substrate receptor for YBX1 (bound via N-terminus to YBX1 CSD). Review core MF = GO:1990756. NOTE: subtype label is "LRR" (IPR032675) but the review/UniProt explicitly state FBXO33 LACKS canonical LRR/WD40 substrate domains and engages substrate via its N-terminus — a minor PN-workbook signature-domain vs biology tension, not a GO mapping error.
- **PN story / NEW pressure:** PN asserts only the generic adaptor MF. Unlike FBXO22/25/30/34, FBXO33's GOA carries NO ubiquitin-ligase/transferase MF annotation to MODIFY (no GO:0061630/0004842; only protein binding IPI, SCF complex CC, SCF catabolism BP). So GO:1990756 in core_functions is **inferred-only** (asserted by the review/PN, not derived from an existing MF annotation). It is well-justified by the YBX1 IDA-grade biology, but technically the adaptor MF is NEW relative to GOA — this is the strongest "ADD GO:1990756 to GOA" candidate among these six. proposed_new_terms empty (correct; no substrate-specific term warranted). Conclusion: PN adaptor claim = defensible ADD to GOA (GO:1990756 verified real).
- **Mapping strategy:** Correct; gene does not change the node. GO:1990756 equals the review's core MF. Because there is no MF annotation in GOA, the PN projection (new_to_goa) genuinely adds value here.
- **Evidence alignment:** PN cites only "15340381 / rev". Review anchored on PMID:16797541 (YB-1 degradation, the founding FBXO33 functional paper) + Falcon (Xiao 2023 EMBO J YBX1/BMSC; Chen 2019 ATXN3; Wei 2024 MYC; Wu 2025 p53) + interactome PMIDs + PMID:34445249. PN reference disjoint from and far thinner than review's.
- **Verdict:** CONSISTENT — no edits required; flag that GO:1990756 core MF is inferred-only (best ADD-to-GOA candidate; substrate-validated by YBX1).