## FBXO34
- **UniProt:** Q9NWN3 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (developed; poorly characterized gene, sparse GOA)
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other` ; **PN-node mapping:** group=mapped GO:1990756; subtype/type/branch=no_mapping; class=context_only (GO:0061630).
- **Consistency:** Strong. Deep research (Falcon → HNRNPU substrate, HIV-1 latency reversal; mouse meiotic CCNB1/MPF role), UniProt and GOA agree on SCF substrate-receptor role. Review core MF = GO:1990756. No contradictions. PMID:36285453 (HNRNPU/HIV) verified, is the UniProt FUNCTION source.
- **PN story / NEW pressure:** PN asserts only the generic adaptor MF. Like FBXO33, FBXO34's GOA has NO ubiquitin-ligase/transferase MF to MODIFY — only protein binding IPI (mostly sticky Y2H KRTAPs), SCF complex CC and SCF catabolism BP (both NAS/ComplexPortal). So GO:1990756 is **inferred-only** here too, justified by the HNRNPU degradation evidence. Substrate repertoire thin (one human substrate); review correctly proposes no substrate-specific NEW terms (proposed_new_terms empty). Conclusion: PN adaptor claim = defensible ADD to GOA (GO:1990756 verified real); flag adaptor MF as inferred-only with a single validated substrate.
- **Mapping strategy:** Correct; gene does not change the node. GO:1990756 equals the review's core MF and genuinely adds value (no MF in GOA). The large block of high-throughput protein-binding IPIs (KRTAPs, MTUS2, KRT40) are correctly kept non-core / flagged as likely non-physiological.
- **Evidence alignment:** PN cites only "15340381 / rev". Review anchored on PMID:36285453 (HNRNPU/HIV, verified) + Falcon (Yang 2022 human; Zhao 2021/Kinterova 2022 mouse meiosis, orthology-based UNVERIFIED) + interactome PMIDs + PMID:34445249. PN reference disjoint from review's.
- **Verdict:** CONSISTENT — no edits required; flag GO:1990756 core MF as inferred-only (one validated substrate, HNRNPU).