## FBXO36
- **UniProt:** Q8NEA4 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other` ; **PN-node mapping:** F-box subtype/type = no_mapping (defer to parent); group "Cul1 substrate receptor" = mapped, ok_for_propagation_to_go, GO:1990756; class = context_only/too_broad (GO:0061630).
- **Consistency:** Fully consistent. Deep research (Falcon), review YAML, PN annotation, and PN-node mapping all converge on "poorly characterized FBXO-class SCF substrate receptor, no validated endogenous substrate." Review ACCEPTs the two ComplexPortal NAS annotations (GO:0019005, GO:0031146) and sets core MF = GO:1990756, matching the projected term. No contradictions.
- **PN story / NEW pressure:** PN asserts only the generic substrate-receptor role, already captured. The strongest functional lead (TNF/NF-kappaB RNAi screen; beta-catenin/SCF-betaTrCP modifier) is correctly held as UNVERIFIED, perturbation-level, no direct substrate — not promoted to a NEW term. proposed_new_terms = []. Conclusion: **already captured**; no defensible NEW term.
- **Mapping strategy:** Gene does not change the node. GO:1990756 (verified real, OLS: "ubiquitin-like ligase-substrate adaptor activity," F-box/BTB adaptors) is the correct, appropriately-scoped MF for an uncharacterized F-box receptor and matches the review core MF. Not over-broad. Mapping status/scope correct.
- **Evidence alignment:** PN cites only "15340381 / rev" (a generic F-box review citation). Review's anchor PMID is PMID:34445249 (ComplexPortal NAS) plus UniProt and Falcon leads — divergent identifiers but same family-level framing; no substrate-level evidence on either side. PN's 15340381 is not in the review references (minor divergence, both generic).
- **Verdict:** Consistent, mapping correct, no NEW pressure. ACCEPT as-is. **Recommended edits:** none.