## FBXO41
- **UniProt:** Q8TF61 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR` ; **PN-node mapping:** F-box subtype/type = no_mapping; group = mapped, ok_for_propagation_to_go, GO:1990756; class = context_only/too_broad (GO:0061630).
- **Consistency:** Consistent. Deep research (Falcon) and review YAML agree on a neuron-specific SCF F-box protein with a centrosomal pool driving cilia disassembly and cerebellar granule-neuron migration. Both primary studies (PMID:31160656, PMID:26063905) are cached full-text and the review correctly states they were read in full (verified: full_text_available=true). PN dossier (generic F-box adaptor) is narrower than the rich review biology but not contradictory. Note: PN/UniProt put the auxiliary domain as LRR, whereas the review describes an N-terminal C2H2 zinc-finger + coiled-coil (not LRR) — a minor domain-annotation divergence, not a functional contradiction.
- **PN story / NEW pressure:** PN asserts only the generic adaptor role. Review adds two verified NEW terms by ISO from mouse/rat: GO:0061523 cilium disassembly (OLS-verified) and GO:0001764 neuron migration — both directly assayed in the read full texts. Defensible. Conclusion: **ADD** GO:0061523 + GO:0001764 (present in review). Core SCF adaptor MF (GO:1990756) already captured; no validated ubiquitination substrate (CUL7/NFM is thesis-level, held preliminary — appropriate).
- **Mapping strategy:** Gene does not change the shared node. GO:1990756 matches; the neuron-specific cilia/migration terms are correctly kept in the review (substrate/process-specific) rather than propagated to the broad PN group node.
- **Evidence alignment:** PN cites only "15340381 / rev." Review anchors on PMID:31160656 and PMID:26063905 (both HIGH/VERIFIED, full text) plus GO_REF:0000107, PMID:34445249, Falcon, Reactome. Strong divergence: review carries the experimental primaries PN lacks.
- **Verdict:** Consistent; well-evidenced verified NEW terms. ACCEPT review. **Recommended edits:** none for YAML; optionally [MAP] note FBXO41 auxiliary domain may be C2H2/coiled-coil rather than LRR in the PN workbook.