## FBXO47
- **UniProt:** Q5MNV8 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other` ; **PN-node mapping:** F-box subtype/type = no_mapping; group = mapped, ok_for_propagation_to_go, GO:1990756; class = context_only/too_broad (GO:0061630).
- **Consistency:** Mostly consistent with a notable tension. Deep research (Falcon: Hua 2019, Guan 2022, Ma 2024) and review YAML agree FBXO47 is a testis/germ-cell F-box protein essential for meiotic prophase I (telomere-INM/TRF2 stabilization, HORMAD1, centromere pairing), where several activities PREVENT rather than promote degradation. Review keeps SCF complex membership (GO:0019005) as KEEP_AS_NON_CORE and marks the SCF-dependent catabolism (GO:0031146) UNDECIDED — honest given conflicting stabilizing/degradative evidence. PN node projects GO:1990756 adaptor activity, which the review also uses as core MF, so they agree at the MF label even though the in vivo role is unusual.
- **PN story / NEW pressure:** PN asserts only the generic adaptor role; the meiotic prophase biology is NOT in GOA. Review sets directly_involved_in GO:0007129 homologous chromosome pairing at meiosis (OLS-verified) and proposes a label-only NEW term for telomere-INM/bouquet attachment (no GO ID invented — candidate, unverified). Conclusion: meiotic-prophase role is real and under-captured; **ADD** GO:0007129 (in review); the bouquet/telomere-INM term is a defensible candidate but currently unverified (label only).
- **Mapping strategy:** Gene does not force a node change, but FBXO47 is a borderline case (stabilizing/non-degradative activities; F-box "other," no firmly validated degradative substrate in vivo). GO:1990756 is acceptable as the family-level MF but the review rightly avoids asserting canonical SCF-dependent degradation. The meiotic terms are correctly kept review-local, not propagated to the broad node.
- **Evidence alignment:** PN cites only "15340381 / rev." Review anchors on UniProt (by-similarity) and Falcon leads (Hua/Guan/Ma, UNVERIFIED, not in cache); PMID:34445249 NAS rated LOW_QUALITY for this gene. Divergence: review carries meiotic primaries as leads; neither side has cache-verified substrate-level PMIDs.
- **Verdict:** Consistent at MF label; meiotic biology appropriately added (GO:0007129) with honest UNDECIDED on SCF catabolism. ACCEPT review. **Recommended edits:** none required; optionally [REF] verify Hua 2019 / Guan 2022 / Ma 2024 PMIDs and [YAML] convert the label-only bouquet term to a real GO ID if one exists (e.g. via OLS) before promotion.