## FBXO6

- **UniProt:** Q9NRD1 (FBXO6/FBG2/Fbs2) · **batch:** proteostasis-batch-2026-06-13 (Falcon DR) · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA` ; **PN-node mapping:** group `Cul1 substrate receptor`=`mapped`/ok_for_propagation→GO:1990756; F-box/FBA subtype+type=`no_mapping`; class=`context_only`/too_broad→GO:0061630.
- **Consistency:** Consistent. Falcon DR (NGLY1/NFE2L1 axis, proteasome bounce-back), review YAML, and the PN FBA F-box receptor placement converge. SPECIAL CASE confirmed: FBA lectin (GO:0030246, verified real) binding high-mannose/complex/sulfated glycans (chitobiose core essential, PMID:18203720), feeding glycoprotein-ERAD; plus a documented CHK1-degradation/checkpoint role (PMID:19716789, IDA).
- **PN story / NEW pressure:** PN projects the generic GO:1990756 adaptor term (new_to_goa). Review's **core MF is GO:0030246 carbohydrate binding (ACCEPT, already in GOA; experimentally grounded by PMID:18203720 glycan-array)** — more informative than the generic adaptor. Catalytic GO:0061630 correctly held at contributes_to/non-core. The CHK1/DNA-damage-checkpoint role (GO:0000077) is a real second process kept non-core; review aptly MARK_AS_OVER_ANNOTATED for the GO:0006281 DNA repair term (FBXO6 terminates CHK1, is not a repair factor). Conclude: gene's distinctive lectin MF already captured; generic PN adaptor term not the best core.
- **Mapping strategy:** Gene refines, does not change, the node — same as FBXO2. GO:1990756 group projection is the safe family MF; GO:0030246 is the more specific, already-in-GOA MF for the FBA-lectin subfamily. PN class GO:0061630 correctly too_broad.
- **Evidence alignment:** PN reference only "15340381 / rev"; review uses gene-specific PMID:18203720 (HIGH/VERIFIED, lectin+SCF), PMID:19716789 (HIGH/VERIFIED, CHK1), PMID:34445249/ComplexPortal CPX-7905, plus Falcon DR (Fujihira/Suzuki NGLY1 review, NFE2L1). PN family review is a subset; good overlap on the SCF-receptor framing.
- **Verdict:** Consistent; core MF correctly GO:0030246 (lectin, in GOA) over the generic PN adaptor term; CHK1 checkpoint role non-core; GO:0006281 over-annotation flagged. No over-reach.
- **Recommended edits:** none to FBXO6-ai-review.yaml. [MAP] As for FBXO2, FBA-lectin subfamily nodes could carry GO:0030246 as the distinguishing MF in addition to GO:1990756.