## FBXO8

- **UniProt:** Q9NRD0 · **batch:** proteostasis-batch-2026-06-13 (Falcon DR) · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other` ; **PN-node mapping:** subtype/type `no_mapping`; group `Cul1 substrate receptor`=`mapped` / `ok_for_propagation_to_go` → GO:1990756 ubiquitin-like ligase-substrate adaptor activity (new_to_goa); class `context_only`/`too_broad` (GO:0061630).
- **Consistency:** Consistent. DR ↔ YAML ↔ PN agree FBXO8 is an SCF/CRL1 F-box substrate receptor; review ACCEPTs the SCF complex (GO:0019005) and SCF-dependent catabolism (GO:0031146), and uses GO:1990756 as the core MF, matching the PN projection. No contradictions; the unusual SEC7/ARF6 angle is kept non-core (predicted GEF, not demonstrated).
- **PN story / NEW pressure:** PN asserts only the family adaptor MF, which is the recurring correct call. GO:1990756 is verified real (def: "Usually mediated by F-box ... proteins"). It is NOT in GOA for FBXO8 (its only MF annotation is GO:0005085 GEF, IEA). So the adaptor MF is a defensible ADD, but note FBXO8 has NO existing catalytic ligase/transferase MF to MODIFY — GO:1990756 currently lives only in `core_functions`, not as a NEW `existing_annotation`. Validated protein substrate exists (GSTP1, PMID:31024008), so this is not a substrate-less F-box.
- **Mapping strategy:** Gene does not change the node; status/scope correct. PN-projected GO:1990756 is at the right altitude (matches review core MF). Class-level GO:0061630 correctly held as too_broad.
- **Evidence alignment:** PN cites only 15340381 (family review). Review is far richer: PMID:31024008 (GSTP1 substrate), PMID:34445249 (SCF/ComplexPortal), PMID:10945468 (cloning), plus Falcon ARF6/Sec7 leads. Divergence is expansion, not conflict.
- **Verdict:** Consistent; PN adaptor mapping (GO:1990756) appropriate and matches review core function.
- **Recommended edits:** [YAML] consider adding GO:1990756 as a NEW `existing_annotation` (MF) to make the adaptor activity an explicit annotation, not only a `core_functions` entry (FBXO8 currently has no curated SCF-adaptor MF in GOA; the only MF is the IEA GEF term, kept non-core). [MAP] none.